KEGG   DRUG: Elosulfase alfa
Entry
D10333                      Drug                                   
Name
Elosulfase alfa (USAN);
Elosulfase alfa (genetical recombination) (JAN);
Vimizim (TN)
Product
VIMIZIM (BioMarin Pharmaceutical)
Formula
C5020H7588N1364O1418S34
Exact mass
110755.4086
Mol weight
110824.4607
Sequence
APQPPNILLL LMDDMGWGDL GVYGEPSRET PLCSPSRAAL LTGRLPIRNG FYTTNAHARN
LLKKAGYVSK IVGKWHLGHR PQFHPLKHGF NIPVYRDWEM VGRYYEEFPI NLKTGEANLT
FLYWAVDATH APVYASKPFL GTSQRGRYGD VADNTFVFFT SDNGAALISA PEQGGSNGPF
PGHVTAGQVS HQLGSIMDLF TTSLALAGLT LMDRPIFYYR GDTLMAATLG QHKAHFWTWT
VTTHNLEDHT KLPLIFHLGR DPGERFPLSF EALVPAQPQL NVCNWAVMNW APPGCEKLGK
PNLDRMAAEG LLFPNFYSAN AYTPQEIVGG IPDSEQLLPE DEWFGSPNCH FGPYDNKARP
QIYLQEALDF IKRQARHHPF AVREIDDSIG KILELLQDLH LCGKQTTFEG GMREPALAWW
PPSDRAIDGL NLLPTLLQGR NSWENFRQGI DFCPGQNVSG ASAEYQEALS RITSVVQQHQ
CLTPPESIPK KCLWSH
(Disulfide bridge: 139-139' 282-393 282'-393' 463-492 463'-492' 475-481 475'-481')
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB12
Product: D10333<JP/US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (N-acetylgalactosamine-6-sulfatase)
  Disease
Mucopolysaccharidosis type IVA [DS:H00123]
  Type
Enzyme replacement therapy product
Target
GALNS* [HSA_VAR:2588v1] [HSA:2588] [KO:K01132]
  Pathway
hsa00531  Glycosaminoglycan degradation
hsa04142  Lysosome
  Network
nt06012  Glycosaminoglycan degradation
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB12 Elosulfase alfa
      D10333  Elosulfase alfa (USAN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Elosulfase Alfa
   D10333  Elosulfase alfa (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D10333  Elosulfase alfa (USAN); Elosulfase alfa (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Sulfatases
    GALNS* [HSA_VAR:2588v1]
     D10333  Elosulfase alfa (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10333
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10333
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10333
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10333
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D10333
Other DBs
CAS: 9025-60-9
PubChem: 172232427
LinkDB

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