KEGG   DRUG: NesvacumabHelp
Entry
D10395                      Drug                                   

Name
Nesvacumab (USAN)
Formula
C6440H9966N1722O2008S38
Exact mass
144770.005
Mol weight
144858.8406
Sequence
(heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SYDIHWVRQA TGKGLEWVSA IGPAGDTYYP
GSVKGRFTIS RENAKNSLYL QMNSLRAGDT AVYYCARGLI TFGGLIAPFD YWGQGTLVTV
SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKKV EPKSCDKTHT CPPCPAPELL
GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ
YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR
DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS
RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(light chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS STYLAWYQQK PGQAPRLLIY GASSRATGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ HYDNSQTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer, disulfide bridge: H22-H95, H149-H205, H225-L214, H231-H'231, H234-H'234, H266-H326, H372-H430, H'22-H'95, H'149-H'205, H'225-L'214, H'266-H'326, H'372-H'430, L23-L89, L134-L194, L'23-L'89, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Angiogenesis inhibitor
Comment
Monoclonal antibody
Target
ANGPT2 [HSA:285] [KO:K05466]
  Pathway
hsa04066  HIF-1 signaling pathway
hsa04151  PI3K-Akt signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Growth factors (RTK-binding)
    ANGPT2
     D10395  Nesvacumab (USAN)
BRITE hierarchy
Other DBs
CAS: 1296818-77-3
PubChem: 172232488
LinkDB All DBs

» Japanese version   » Back

DBGET integrated database retrieval system