KEGG   DRUG: EldelumabHelp
Entry
D10404                      Drug                                   

Name
Eldelumab (USAN)
Formula
C6502H10024N1736O2026S48
Exact mass
146376.131
Mol weight
146466.6976
Sequence
(Heavy chain)
QMQLVESGGG VVQPGRSLRL SCTASGFTFS NNGMHWVRQA PGKGLEWVAV IWFDGMNKFY
VDSVKGRFTI SRDNSKNTLY LEMNSLRAED TAIYYCAREG DGSGIYYYYG MDVWGQGTTV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK RVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPG
(Light chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GASSRATGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPIFTF GPGTKVDIKR TVAAPSVFIF
PPSDEQLKSG TASVVCLLNN FYPREAKVQW KVDNALQSGN SQESVTEQDS KDSTYSLSST
LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC
(dimer)
(disulfide bridges: H22-H96, H151-H207, H227-L216, H233-H'233, H236-H'236, H268-H328, H374-H432, H'22-H'96, H'151-H'207, H'227-L'216, H'268-H'328, H'374-H'432, L23-L89, L136-L196, L'23-L'89, L'136-L'196)
(modified residues: H1, H'1 Q=pyroglutamic acid [CPD:C01879])
(glycosylation site: H304, H'304)
  Type
Peptide
Efficacy
Anti-inflammatory, Anti-CXCL10 antibody
Comment
Monoclonal antibody
Treatment of Crohn's disease, ulcerative colitis, and other autoimmune diseases
Target
CXCL10 [HSA:3627] [KO:K12671]
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Chemokines
    CXCL10
     D10404  Eldelumab (USAN)
BRITE hierarchy
Other DBs
CAS: 946414-98-8
PubChem: 172232497
LinkDB All DBs

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