KEGG   DRUG: TovetumabHelp
Entry
D10411                      Drug                                   

Name
Tovetumab (USAN)
Formula
C6400H9906N1726O2002S54
Exact mass
144701.1314
Mol weight
144791.0066
Sequence
(Heavy chain)
QVQLVESGGG LVKPGGSLRL SCAASGFTFS DYYMNWIRQA PGKGLEWVSY ISSSGSIIYY
ADSVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCAREG RIAARGMDVW GQGTTVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER KCCVECPPCP APPVAGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTFR
VVSVLTVVHQ DWLNGKEYKC KVSNKGLPAP IEKTISKTKG QPREPOVYTL PPSREEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT VDKSRWQQGN
VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVS ITCRPSQSFS RYINWYQQKP GKAPKLLIHA ASSLVGGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ TYSNPPITFG QGTRLEMKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(dimer; disulfide bridges: H22-H96, H'22-H'96, L23-L88, L'23-L'88, H134-L215, H'134-L'215, L135-L195, L'135-L'195, H147-H203, H'147-H'203, H222-H'222, H223-H'223, H226-H'226, H229-H'229, H260-H320, H'260-H'320, H366-H424, H'366-H'424; glycosylation sites (N)
Asn-H296, Asn-H'296)
  Type
Peptide
Efficacy
Antineoplastic, Anti-platelet-derived growth factor receptor alpha antibody
Comment
Monoclonal antibody
Target
PDGFRA [HSA:5156] [KO:K04363]
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFRA
     D10411  Tovetumab (USAN)
BRITE hierarchy
Other DBs
CAS: 1243266-04-7
PubChem: 172232504
LinkDB All DBs

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