KEGG   DRUG: BezlotoxumabHelp
Entry
D10453                      Drug                                   

Name
Bezlotoxumab (USAN/INN);
Bezlotoxumab (genetical recombination) (JAN);
Zinplava (TN)
Product
Formula
C6464H9974N1726O2014S46
Exact mass
145473.8259
Mol weight
145563.7042
Sequence
(Heavy chain)
EVQLVQSGAE VKKSGESLKI SCKGSGYSFT SYWIGWVRQM PGKGLEWMGI FYPGDSSTRY
SPSFQGQVTI SADKSVNTAY LQWSSLKASD TAMYYCARRR NWGNAFDIWG QGTMVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GASSRATGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSTWTFG QGTKVEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(dimer; disulfide bridges: H22-H96, H146-H202, H222-L215, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'96, H'146-H'202, H'222-L'215, H'263-H'323, H'369-H'427, L23-L89, L135-L195, L'23-L'89, L'135-L'195)
  Type
Peptide
Remark
Therapeutic category: 6399
ATC code: J06BB21
Product: D10453<JP/US>
Efficacy
Antibacterial, Antitoxin
Comment
Monoclonal antibody
Prevention of recurrence of Clostridium difficile infection (CDI)
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J06 IMMUNE SERA AND IMMUNOGLOBULINS
   J06B IMMUNOGLOBULINS
    J06BB Specific immunoglobulins
     J06BB21 Bezlotoxumab
      D10453  Bezlotoxumab (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D10453  Bezlotoxumab (USAN/INN); Bezlotoxumab (genetical recombination) (JAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10453
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10453
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10453
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10453
BRITE hierarchy
Other DBs
CAS: 1246264-45-8
PubChem: 172232546
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