KEGG   DRUG: SerelaxinHelp
Entry
D10488                      Drug                                   

Name
Serelaxin (USAN/INN);
Serelaxin (genetical recombination) (JAN)
Formula
C256H408N74O74S8
Exact mass
5958.8203
Mol weight
5962.9501
Sequence
(Heavy chain)
DSWMEEVIKL CGRELVRAQI AICGMSTWS
(Light chain)
QLYSALANKC CHVGCTKRSL ARFC
(disulfide bridges: H11-L11, H23-L24, L10-L15)
(modified residues: L1:Q=L-pyroglutamic acid [CPD:C01879])
  Type
Peptide
Remark
ATC code: C01DX21
Efficacy
Vasodilator, Relaxin receptor agonist
Comment
Recombinant human relaxin-2 [HSA:6019] [KO:K05255]
Treatment of acute heart failure
Target
RXFP1 [HSA:59350] [KO:K04306]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04926  Relaxin signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DX Other vasodilators used in cardiac diseases
     C01DX21 Serelaxin
      D10488  Serelaxin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Endocrine system
   Relaxin signaling
    RXFP1
     D10488  Serelaxin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 99489-94-8
PubChem: 172232581
LinkDB All DBs

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