KEGG   DRUG: Aducanumab
Entry
D10541                      Drug                                   

Name
Aducanumab (USAN);
Aducanumab (genetical recombination) (JAN);
Aduhelm (TN)
Product
Formula
C6472H10028N1740O2014S46
Exact mass
145820.2915
Mol weight
145910.3123
Sequence
(Heavy chain)
XVQLVESGGG VVQPGRSLRL SCAASGFAFS SYGMHWVRQA PGKGLEWVAV IWFDGTKKYY
TDSVKGRFTI SRDNSKNTLY LQMNTLRAED TAVYYCARDR GIGARRGPYY MDVWGKGTTV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK RVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H151-H207, H227-L214, H233-H'233, H236-H'236, H268-H328, H374-H432, H'22-H'96, H'151-H'207, H'227-L'214, H'268-H'328, H'374-H'432, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Neuropsychiatric agent
 DG01968  Antidementia agent
Remark
ATC code: N06DX03
Product: D10541<US>
Efficacy
Dementia therapeutic agent
  Disease
Alzheimer's disease [DS:H00056]
Comment
Monoclonal antibody
Treatment of Alzheimers disease
Target
Amyloid beta [CPD:C16514 C16515]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX03 Aducanumab
      D10541  Aducanumab (USAN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01968  Antidementia agent
   D10541  Aducanumab
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10541
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10541
Other DBs
CAS: 1384260-65-4
PubChem: 254741503
LinkDB

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