KEGG   DRUG: AducanumabHelp
Entry
D10541                      Drug                                   

Name
Aducanumab (USAN)
Formula
C6472H10028N1740O2014S46
Exact mass
145820.2915
Mol weight
145910.3123
Sequence
(heavy chain)
XVQLVESGGG VVQPGRSLRL SCAASGFAFS SYGMHWVRQA PGKGLEWVAV IWFDGTKKYY
TDSVKGRFTI SRDNSKNTLY LQMNTLRAED TAVYYCARDR GIGARRGPYY MDVWGKGTTV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK RVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPG
(light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; disulfide bridge: H22-H96, H151-H207, H227-L214, H233-H'233, H236-H'236, H268-H328, H374-H432, H'22-H'96, H'151-H'207, H'227-L'214, H'268-H'328, H'374-H'432, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Neuropsychiatric agent
 DG01968  Agents for Alzheimer-type dementia
Efficacy
Dementia therapeutic agent
Comment
Monoclonal antibody
Treatment of Alzheimers disease
Target
beta-amyloid
Interaction
Drug interaction
Other DBs
CAS: 1384260-65-4
PubChem: 254741503
LinkDB All DBs

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