Aducanumab (USAN);
Aducanumab (genetical recombination) (JAN);
Aduhelm (TN)

C6472H10028N1740O2014S46

145820.2915

145910.40

(Heavy chain)
XVQLVESGGG VVQPGRSLRL SCAASGFAFS SYGMHWVRQA PGKGLEWVAV IWFDGTKKYY
TDSVKGRFTI SRDNSKNTLY LQMNTLRAED TAVYYCARDR GIGARRGPYY MDVWGKGTTV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK RVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H151-H207, H227-L214, H233-H'233, H236-H'236, H268-H328, H374-H432, H'22-H'96, H'151-H'207, H'227-L'214, H'268-H'328, H'374-H'432, L23-L88, L134-L194, L'23-L'88, L'134-L'194)

Dementia therapeutic agent

Treatment of Alzheimers disease

Amyloid beta [CPD:C16514 C16515]

Donanemab (USAN/INN);
Donanemab (genetical recombination) (JAN);
Donanemab-azbt;
Kisunla (TN)

C6452H10038N1708O2013S42

144998.3882

145087.78

(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYDFT RYYINWVRQA PGQGLEWMGW INPGSGNTKY
NEKFKGRVTI TADESTSTAY MELSSLRSED TAVYYCAREG ITVYWGQGTT VTVSSASTKG
PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV
VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV
FSCSVMHEAL HNHYTQKSLS LSPG
(Light chain)
DIVMTQTPLS LSVTPGQPAS ISCKSSQSLL YSRGKTYLNW LLQKPGQSPQ LLIYAVSKLD
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCVQGTHYP FTFGQGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H142-H198, H218-L219, H224-H'224, H227-H'227, H259-H319, H365-H423, H'22-H'96, H'142-H'198, H'218-L'219, H'259-H'319, H'365-H'423, L23-L93, L139-L199, L'23-L'93, L'139-L'199)

Dementia therapeutic agent

Treatment of Alzheimer's disease

Amyloid beta [CPD:C16514 C16515]

Lecanemab (USAN);
Lecanemab (genetical recombination) (JAN);
Leqembi (TN)

C6544H10088N1744O2032S46

147088.6818

147179.66

(Heqvy chain)
EVQLVESGGG LVQPGGSLRL SCSASGFTFS SFGMHWVRQA PGKGLEWVAY ISSGSSTIYY
GDTVKGRFTI SRDNAKNSLF LQMSSLRAED TAVYYCAREG GYYYGRSYYT MDYWGQGTTV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK RVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGK
(Light chain)
DVVMTQSPLS LPVTPGAPAS ISCRSSQSIV HSNGNTYLEW YLQKPGQSPK LLIYKVSNRF
SGVPDRFSGS GSGTDFTLRI SRVEAEDVGI YYCFQGSHVP PTFGPGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H151-H207, H227-L219, H233-H'233, H236-H'236, H268-H328, H374-H432, H'22-H'96, H'151-H'207, H'227-H'219, H'268-H'328, H'374-H'432, L23-L93, L139-L199, L'23-L'93, L'139-L'199)

Dementia therapeutic agent

Treatment of Alzheimer's disease

Amyloid beta [CPD:C16514 C16515]