KEGG   DRUG: Macimorelin acetateHelp
Entry
D10562                      Drug                                   

Name
Macimorelin acetate (USAN);
Macrilen (TN)
Product
Formula
C26H30N6O3. C2H4O2
Exact mass
534.2591
Mol weight
534.6068
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
ATC code: V04CD06
Chemical structure group: DG01879
Product (DG01879): D10562<US>
Efficacy
Diagnostic (adult growth hormone deficiency (AGHD)), Growth hormone secretagogue receptor (GHSR) /ghrelin receptor agonist
Target
GHSR [HSA:2693] [KO:K04284]
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V04 DIAGNOSTIC AGENTS
   V04C OTHER DIAGNOSTIC AGENTS
    V04CD Tests for pituitary function
     V04CD06 Macimorelin
      D10562  Macimorelin acetate (USAN) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Ghrelin
    GHSR
     D10562  Macimorelin acetate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10562
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10562
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10562
BRITE hierarchy
Other DBs
CAS: 945212-59-9
PubChem: 254741524
ChEMBL: CHEMBL2364617
LinkDB All DBs
KCF data Show

ATOM        39
            1   C1b C    26.9856  -17.4751
            2   C1c C    28.1846  -16.7698
            3   C8y C    25.7865  -16.7698
            4   N1b N    29.3837  -17.4751
            5   C5a C    30.5828  -16.7698
            6   C1c C    31.7818  -17.4751
            7   O5a O    30.5828  -15.3590
            8   N1b N    28.1846  -15.3590
            9   C8y C    24.4464  -17.1930
            10  C8y C    23.6000  -16.0644
            11  N4x N    24.4464  -14.9358
            12  C8x C    25.7865  -15.3590
            13  C8x C    23.8821  -18.4626
            14  C8x C    22.4715  -18.6037
            15  C8x C    21.6251  -17.4751
            16  C8x C    22.2599  -16.2054
            17  C4a C    26.9856  -14.6537
            18  O4a O    26.9856  -13.2430
            19  C1b C    32.9810  -16.7698
            20  C8y C    34.1801  -17.4751
            21  C8y C    35.5202  -17.0519
            22  C8y C    36.2961  -18.2510
            23  N4x N    35.4497  -19.3089
            24  C8x C    34.1801  -18.8857
            25  C8x C    36.1550  -15.7822
            26  C8x C    37.5657  -15.7117
            27  C8x C    38.3415  -16.8403
            28  C8x C    37.7067  -18.1099
            29  N1b N    31.7818  -18.8857
            30  C5a C    30.5828  -19.5910
            31  O5a O    29.3837  -18.8857
            32  C1d C    30.5828  -21.0017
            33  C1a C    29.1721  -21.0017
            34  C1a C    31.9934  -21.0017
            35  N1a N    30.5828  -22.4125
            36  C6a C    37.9400  -21.9100
            37  C1a C    39.1524  -22.6100
            38  O6a O    36.7276  -22.6100
            39  O6a O    37.9400  -20.5100
BOND        41
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     4   5 1
            5     5   6 1
            6     5   7 2
            7     2   8 1 #Down
            8     3   9 1
            9     9  10 1
            10   11  12 1
            11    3  12 2
            12   11  10 1
            13    9  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   10  16 2
            18    8  17 1
            19   17  18 2
            20    6  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   20  24 2
            27   21  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   22  28 2
            32    6  29 1 #Up
            33   29  30 1
            34   30  31 2
            35   30  32 1
            36   32  33 1
            37   32  34 1
            38   32  35 1
            39   36  37 1
            40   36  38 1
            41   36  39 2

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