KEGG   DRUG: Pasireotide pamoate
Entry
D10566                      Drug                                   
Name
Pasireotide pamoate (JAN);
Signifor lar (TN)
Product
SIGNIFOR LAR (Recordati Rare Diseases)
Formula
C58H66N10O9. C23H16O6
Exact mass
1434.5961
Mol weight
1435.5758
Structure
Class
Hormonal agent
 DG01588  Somatostatin receptor agonist
Remark
Therapeutic category: 2499
ATC code: H01CB05
Chemical structure group: DG00503
Product (DG00503): D10497<US> D10566<JP/US>
Efficacy
Antisecretory, Somatostatin receptor agonist
  Disease
Acromegaly [DS:H01483]
Cushing’s disease [DS:H01431]
Target
SSTR1 [HSA:6751] [KO:K04217]
SSTR2 [HSA:6752] [KO:K04218]
SSTR3 [HSA:6753] [KO:K04219]
SSTR5 [HSA:6755] [KO:K04221]
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01C HYPOTHALAMIC HORMONES
    H01CB Somatostatin and analogues
     H01CB05 Pasireotide
      D10566  Pasireotide pamoate (JAN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Pituitary)
  Pasireotide
   D10566  Pasireotide pamoate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D10566  Pasireotide pamoate (JAN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01588  Somatostatin receptor agonist
   DG00503  Pasireotide
    D10566  Pasireotide pamoate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Somatostatin
    SSTR1
     D10566  Pasireotide pamoate (JAN) <JP/US>
    SSTR2
     D10566  Pasireotide pamoate (JAN) <JP/US>
    SSTR3
     D10566  Pasireotide pamoate (JAN) <JP/US>
    SSTR5
     D10566  Pasireotide pamoate (JAN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10566
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10566
Drug groups [BR:br08330]
 Hormonal agent
  DG01588  Somatostatin receptor agonist
   DG00503  Pasireotide
Other DBs
PubChem: 254741528
LinkDB
KCF data

ATOM        106
            1   C1y C    20.5800  -18.7600
            2   C1b C    21.7700  -19.4600
            3   N1x N    19.3900  -19.4600
            4   C5x C    20.5800  -17.3600
            5   C1b C    22.9600  -18.7600
            6   C1b C    24.1500  -19.4600
            7   C1b C    25.3400  -18.7600
            8   N1a N    26.5300  -19.4600
            9   N1x N    21.7700  -16.6600
            10  O5x O    19.3900  -16.6600
            11  C5x C    18.2000  -18.7600
            12  C1y C    17.0100  -19.4600
            13  O5x O    18.2000  -17.3600
            14  N1x N    15.8200  -18.7600
            15  C1b C    17.0100  -20.8600
            16  C8y C    18.2000  -21.5600
            17  C8y C    18.6200  -22.8900
            18  C8y C    20.0200  -22.8900
            19  N4x N    20.4400  -21.5600
            20  C8x C    19.3200  -20.7200
            21  C8x C    17.9200  -24.0800
            22  C8x C    18.6200  -25.3400
            23  C8x C    20.0200  -25.3400
            24  C8x C    20.7200  -24.0800
            25  C1y C    21.7700  -15.2600
            26  C1b C    22.9600  -14.5600
            27  C5x C    20.5800  -14.5600
            28  O5x O    19.3900  -15.2600
            29  N1x N    20.5800  -13.1600
            30  C8y C    24.1500  -15.2600
            31  C8x C    24.1500  -16.6600
            32  C8x C    25.4100  -17.3600
            33  C8y C    26.6000  -16.6600
            34  C8x C    26.6000  -15.2600
            35  C8x C    25.4100  -14.5600
            36  O2a O    27.7900  -17.3600
            37  C1b C    29.0500  -16.6600
            38  C8y C    30.2400  -17.3600
            39  C8x C    30.2400  -18.7600
            40  C8x C    31.5000  -19.4600
            41  C8x C    32.6900  -18.7600
            42  C8x C    32.6900  -17.3600
            43  C8x C    31.5000  -16.6600
            44  C1y C    19.3900  -12.4600
            45  C5x C    18.2000  -13.1600
            46  C1b C    19.3900  -10.9900
            47  C8y C    20.5800  -10.2900
            48  C8x C    21.7700  -10.9900
            49  C8x C    23.0300  -10.2900
            50  C8x C    23.0300   -8.8900
            51  C8x C    21.8400   -8.1900
            52  C8x C    20.5800   -8.8900
            53  N1y N    17.0100  -12.4600
            54  O5x O    18.2000  -14.5600
            55  C5x C    15.8200  -17.3600
            56  O5x O    17.0100  -16.6600
            57  C1y C    14.6300  -16.6600
            58  C8y C    13.4400  -17.3600
            59  N1x N    14.6300  -15.2600
            60  C8x C    12.2500  -16.6600
            61  C8x C    10.9200  -17.3600
            62  C8x C    10.9200  -18.7600
            63  C8x C    12.1800  -19.4600
            64  C8x C    13.4400  -18.7600
            65  C5x C    15.8200  -14.5600
            66  O5x O    17.0100  -15.2600
            67  C1y C    15.8200  -13.1600
            68  C1x C    16.8700  -11.1300
            69  C1x C    14.8400  -12.1100
            70  C1y C    15.4700  -10.8500
            71  O7a O    14.8400   -9.5900
            72  C7a C    13.5100   -9.6600
            73  O6a O    12.7400   -8.4000
            74  N1b N    12.8100  -10.8500
            75  C1b C    11.4100  -10.8500
            76  C1b C    10.7800  -12.1100
            77  N1a N     9.3100  -12.1100
            78  C8y C    42.4200  -14.3500
            79  C8y C    42.4200  -15.7500
            80  C8y C    43.6100  -16.4500
            81  C8y C    44.8700  -15.7500
            82  C8x C    44.8700  -14.3500
            83  C8y C    43.6100  -13.6500
            84  C8x C    43.6100  -17.8500
            85  C8x C    44.8700  -18.5500
            86  C8x C    46.0600  -17.8500
            87  C8x C    46.0600  -16.4500
            88  O1a O    41.2300  -13.6500
            89  C6a C    43.6100  -12.2500
            90  O6a O    42.3500  -11.5500
            91  O6a O    44.8000  -11.5500
            92  C1b C    40.7400  -16.9400
            93  C8y C    39.0600  -14.3500
            94  C8y C    39.0600  -15.7500
            95  C8y C    37.8700  -16.4500
            96  C8y C    36.6100  -15.7500
            97  C8x C    36.6100  -14.3500
            98  C8y C    37.8700  -13.6500
            99  C8x C    37.8700  -17.8500
            100 C8x C    36.6100  -18.5500
            101 C8x C    35.4200  -17.8500
            102 C8x C    35.4200  -16.4500
            103 O1a O    40.2500  -13.6500
            104 C6a C    37.8700  -12.2500
            105 O6a O    39.1300  -11.5500
            106 O6a O    36.6800  -11.5500
BOND        116
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     4   9 1
            9     4  10 2
            10    3  11 1
            11   11  12 1
            12   11  13 2
            13   12  14 1
            14   12  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   16  20 2
            21   17  21 2
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   18  24 2
            26    9  25 1
            27   25  26 1
            28   25  27 1
            29   27  28 2
            30   27  29 1
            31   26  30 1
            32   30  31 2
            33   31  32 1
            34   32  33 2
            35   33  34 1
            36   34  35 2
            37   30  35 1
            38   33  36 1
            39   36  37 1
            40   37  38 1
            41   38  39 2
            42   39  40 1
            43   40  41 2
            44   41  42 1
            45   42  43 2
            46   38  43 1
            47   29  44 1
            48   44  45 1
            49   44  46 1
            50   46  47 1
            51   47  48 2
            52   48  49 1
            53   49  50 2
            54   50  51 1
            55   51  52 2
            56   47  52 1
            57   45  53 1
            58   45  54 2
            59   14  55 1
            60   55  56 2
            61   55  57 1
            62   57  58 1
            63   57  59 1
            64   58  60 2
            65   60  61 1
            66   61  62 2
            67   62  63 1
            68   63  64 2
            69   58  64 1
            70   59  65 1
            71   65  66 2
            72   65  67 1
            73   53  67 1
            74   53  68 1
            75   67  69 1
            76   69  70 1
            77   68  70 1
            78   70  71 1 #Up
            79   71  72 1
            80   72  73 2
            81   72  74 1
            82   74  75 1
            83   75  76 1
            84   76  77 1
            85   78  79 2
            86   79  80 1
            87   80  81 2
            88   81  82 1
            89   82  83 2
            90   78  83 1
            91   80  84 1
            92   84  85 2
            93   85  86 1
            94   86  87 2
            95   81  87 1
            96   78  88 1
            97   83  89 1
            98   89  90 2
            99   89  91 1
            100  79  92 1
            101  93  94 2
            102  94  95 1
            103  95  96 2
            104  96  97 1
            105  97  98 2
            106  93  98 1
            107  95  99 1
            108  99 100 2
            109 100 101 1
            110 101 102 2
            111  96 102 1
            112  93 103 1
            113  98 104 1
            114 104 105 2
            115 104 106 1
            116  94  92 1

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