KEGG   DRUG: Asfotase alfaHelp
Entry
D10595                      Drug                                   

Name
Asfotase alfa (USAN/INN);
Asfotase alfa (genetical recombination) (JAN);
Strensiq (TN)
Product
Formula
C7108H11008N1968O2206S56
Exact mass
161023.4052
Mol weight
161122.9611
Sequence
LVPEKEKDPK YWRDQAQETL KYALELQKLN TNVAKNVIMF LGDGMGVSTV TAARILKGQL
HHNPGEETRL EMDKFPFVAL SKTYNTNAQV PDSAGTATAY LCGVKANEGT VGVSAATERS
RCNTTQGNEV TSILRWAKDA GKSVGIVTTT RVNHATPSAA YAHSADRDWY SDNEMPPEAL
SQGCKDIAYQ LMHNIRDIDV IMGGGRKYMY PKNKTDVEYE SDEKARGTRL DGLDLVDTWK
SFKPRYKHSH FIWNRTELLT LDPHNVDYLL GLFEPGDMQY ELNRNNVTDP SLSEMVVVAI
QILRKNPKGF FLLVEGGRID HGHHEGKAKQ ALHEAVEMDR AIGQAGSLTS SEDTLTVVTA
DHSHVFTFGG YTPRGNSIFG LAPMLSDTDK KPFTAILYGN GPGYKVVGGE RENVSMVDYA
HNNYQAQSAV PLRHETHGGE DVAVFSKGPM AHLLHGVHEQ NYVPHVMAYA ACIGANLGHC
APASSLKDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV
KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE
KTISKAKGQP REPQVYTLPP SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT
TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKDIDDDD
DDDDDD
(Disulfide bridge: 122-184, 472-480, 493-493', 496-496', 528-588, 634-692, 122'-184', 472'-480', 528'-588', 634'-692')
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB13
Product: D10595<JP/US>
Efficacy
Enzyme replacement (akaline phosphatase)
  Disease
Hypophosphatasia [DS:H00213]
Comment
Enzyme replacement therapy product
Target
ALPL* [HSA_VAR:249v1] [HSA:249] [KO:K01077]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB13 Asfotasealfa
      D10595  Asfotase alfa (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic or Enzyme Disorder: Replacement, Modifiers, Treatment
  Asfotase Alfa
   D10595  Asfotase alfa (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D10595  Asfotase alfa (USAN/INN); Asfotase alfa (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphatases
    ALPL* [HSA_VAR:249v1]
     D10595  Asfotase alfa (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10595
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10595
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10595
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10595
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D10595
BRITE hierarchy
Other DBs
CAS: 1174277-80-5
PubChem: 254741557
LinkDB All DBs

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