| Entry |
|
|---|
| Name |
Briciclib (USAN/INN) |
|---|
| Formula |
C19H23O10PS
|
|---|
| Exact mass |
474.0750
|
|---|
| Mol weight |
474.42
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic |
|---|
| Comment |
Briciclib binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins (c-MYC, VEGF), leading to tumor cell death.
|
|---|
| Target |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Genetic information processing
Translation factor
EIF4E
D10614 Briciclib (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 31
1 C8y C 13.0989 -14.4298
2 C8x C 13.0989 -15.8307
3 C8y C 14.3121 -16.5312
4 C8y C 15.5254 -15.8307
5 C8y C 15.5254 -14.4298
6 C8x C 14.3121 -13.7293
7 O2a O 11.8857 -13.7293
8 C1a C 10.6724 -14.4298
9 O2a O 14.3121 -17.9321
10 C1a C 13.0989 -18.6326
11 O2a O 16.7386 -13.7293
12 C1a C 16.7386 -12.3284
13 C2b C 16.7386 -16.5312
14 C2b C 17.9520 -15.8307
15 S4a S 19.1652 -16.5312
16 O3c O 18.1746 -17.5218
17 C1b C 20.3776 -15.8312
18 C8y C 21.5900 -16.5312
19 O3c O 20.1551 -17.5212
20 C8x C 21.5897 -17.9197
21 C8x C 22.8020 -18.6199
22 C8y C 24.0146 -17.9201
23 C8y C 24.0149 -16.5317
24 C8x C 22.8026 -15.8314
25 O2a O 25.2270 -18.6201
26 C1a C 26.4395 -17.9201
27 O2b O 25.2273 -15.8317
28 P1b P 25.2273 -14.4317
29 O1c O 23.8273 -14.4317
30 O1c O 26.6273 -14.4317
31 O1c O 25.2273 -13.0317
BOND 32
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 7 8 1
9 3 9 1
10 9 10 1
11 5 11 1
12 11 12 1
13 4 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 15 17 1
18 17 18 1
19 15 19 2
20 18 20 2
21 20 21 1
22 21 22 2
23 22 23 1
24 23 24 2
25 18 24 1
26 22 25 1
27 25 26 1
28 23 27 1
29 27 28 1
30 28 29 2
31 28 30 1
32 28 31 1
|
|---|
