KEGG   DRUG: Plazomicin sulfate
Entry
D10655                      Drug                                   
Name
Plazomicin sulfate (USAN);
Zemdri (TN)
Product
ZEMDRI (PLAZOMICIN) (Achaogen), ZEMDRI (PLAZOMICIN) (Cipla Therapeutics), ZEMDRI (PLAZOMICIN) (Cipla USA)
Formula
C25H48N6O10. xH2SO4
Structure
Simcomp
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
ATC code: J01GB14
Chemical structure group: DG01833
Product (DG01833): D10655<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Aminoglycoside
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB14 Plazomicin
      D10655  Plazomicin sulfate (USAN) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Plazomicin
    D10655  Plazomicin sulfate (USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   DG01833  Plazomicin
    D10655  Plazomicin sulfate
Drug classes [BR:br08332]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   D10655  Plazomicin sulfate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    D10655  Plazomicin sulfate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10655
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10655
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D10655
Drug groups [BR:br08330]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   DG01833  Plazomicin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    DG01833  Plazomicin
Other DBs
CAS: 1380078-95-4
PubChem: 254741616
LinkDB
KCF data

ATOM        46
            1   C1x C     9.1223  -17.7189
            2   C1z C     9.1223  -19.1143
            3   C1y C    10.3782  -19.8120
            4   C1y C    11.5642  -19.1143
            5   C1y C    11.5642  -17.7189
            6   O2x O    10.3782  -17.0212
            7   O2a O    12.8201  -17.0212
            8   O1a O    12.8201  -19.8817
            9   N1b N    10.3782  -21.2073
            10  O1a O     7.7270  -19.1143
            11  C1a C     8.4246  -20.3701
            12  C1a C     9.1223  -21.9748
            13  C1y C    14.0061  -16.3235
            14  C1y C    15.2620  -17.0212
            15  C1x C    16.4480  -16.3235
            16  C1y C    16.4480  -14.9282
            17  C1y C    15.1922  -14.2305
            18  C1y C    14.0061  -14.9282
            19  N1b N    15.2620  -18.4166
            20  O1a O    12.8201  -14.2305
            21  N1a N    17.7039  -14.2305
            22  C5a C    16.4480  -19.1143
            23  C1c C    17.6341  -18.4166
            24  O5a O    16.4480  -20.5096
            25  C1b C    18.8202  -19.1143
            26  O1a O    17.6341  -17.0212
            27  C1b C    20.0062  -18.4166
            28  N1a N    21.1923  -19.1143
            29  O2a O    15.1922  -12.8351
            30  C1y C    16.4480  -12.1374
            31  O2x O    17.6341  -12.8351
            32  C2y C    18.8202  -12.1374
            33  C2x C    18.8202  -10.7420
            34  C1x C    17.6341  -10.0444
            35  C1y C    16.4480  -10.7420
            36  N1a N    15.1922  -10.0444
            37  C1b C    20.0760  -12.8351
            38  N1b N    20.0760  -14.2305
            39  C1b C    21.2621  -14.9282
            40  C1b C    22.4481  -14.2305
            41  O1a O    23.6342  -14.9282
            42  O1d O    26.3552  -19.1143
            43  S4a S    26.3552  -20.5096
            44  O1d O    26.3552  -21.9050
            45  O1d O    27.7505  -20.5096
            46  O1d O    24.9598  -20.5096
BOND        47
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     4   8 1 #Down
            9     3   9 1 #Up
            10    2  10 1 #Up
            11    2  11 1 #Down
            12    9  12 1
            13   13   7 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   14  19 1 #Up
            21   18  20 1 #Up
            22   16  21 1 #Up
            23   19  22 1
            24   22  23 1
            25   22  24 2
            26   23  25 1
            27   23  26 1 #Up
            28   25  27 1
            29   27  28 1
            30   17  29 1 #Down
            31   30  29 1 #Down
            32   30  31 1
            33   31  32 1
            34   32  33 2
            35   33  34 1
            36   34  35 1
            37   30  35 1
            38   35  36 1 #Down
            39   32  37 1
            40   37  38 1
            41   38  39 1
            42   39  40 1
            43   40  41 1
            44   42  43 2
            45   43  44 2
            46   43  45 1
            47   43  46 1
BRACKET     1    23.9400  -22.4000   23.9400  -18.4100
            1    28.9100  -18.4100   28.9100  -22.4000
            1  x
 ORIGINAL  1   42  43  44  45  46
 REPEAT    1

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