KEGG   DRUG: IdarucizumabHelp
Entry
D10741                      Drug                                   

Name
Idarucizumab (USAN/INN);
Idarucizumab (genetical recombination) (JAN);
Praxbind (TN)
Product
Sequence
(Heavy chain)
QVQLQESGPG LVKPSETLSL TCTVSGFSLT SYIVDWIRQP PGKGLEWIGV IWAGGSTGYN
SALRSRVSIT KDTSKNQFSL KLSSVTAADT AVYYCASAAY YSYYNYDGFA YWGQGTLVTV
SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKKV EPKSC
(Light chain)
DVVMTQSPLS LPVTLGQPAS ISCKSSQSLL YTDGKTYLYW FLQRPGQSPR RLIYLVSKLD
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCLQSTHFP HTFGGGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(disulfide bridges: H22-H95, H149-H205, H225-L-219, L23-L93, L139-L199)
  Type
Peptide
Remark
Therapeutic category: 3399
ATC code: V03AB37
Product: D10741<JP/US>
Efficacy
Neutralizer (dabigatran)
Comment
Monoclonal antibody
Reversal of anticoagulant effects of dabigatran [DR:D07082]
Target
Dabigatran [DR:D07082] [DG:DG00164]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB37 Idarucizumab
      D10741  Idarucizumab (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D10741  Idarucizumab (USAN/INN); Idarucizumab (genetical recombination) (JAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10741
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10741
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10741
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10741
BRITE hierarchy
Other DBs
CAS: 1362509-93-0
PubChem: 254741702
LinkDB All DBs

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