KEGG   DRUG: DaratumumabHelp
Entry
D10777                      Drug                                   

Name
Daratumumab (USAN);
Daratumumab (genetical recombination) (JAN);
Darzalex (TN)
Product
Formula
C6466H9996N1724O2010S42
Exact mass
145300.124
Mol weight
145389.6292
Sequence
(Heavy chain)
EVQLLESGGG LVQPGGSLRL SCAVSGFTFN SFAMSWVRQA PGKGLEWVSA ISGSGGGTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYFCAKDK ILWFGEPVFD YWGQGTLVTV
SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV EPKSCDKTHT CPPCPAPELL
GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ
YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR
EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS
RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP GQAPRLLIYD ASNRATGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPPTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; disulfide bridge: H22-H96, H149-H205, H225-L214, H231-H'231, H234-H'234, H266-H326, H372-H430, H'22-H'96, H'149-H'205, H'225-L'214, H'266-H'326, H'372-H'430, L23-L88, L134-L194, L'23-L'88, L'134, L'194)
  Type
Peptide
Remark
Therapeutic category: 4291
ATC code: L01XC24
Product: D10777<JP/US>
Efficacy
Antineoplastic, Anti-CD38 antibody
  Disease
Multiple myeloma [DS:H00010]
Comment
Monoclonal antibody
Target
CD38 [HSA:952] [KO:K01242]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC24 Daratumumab
      D10777  Daratumumab (USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D10777  Daratumumab (USAN); Daratumumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ADP-ribosyl cyclase
    CD38
     D10777  Daratumumab (USAN) <JP/US>
Antineoplastics [br08340.html]
 D10777
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10777
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10777
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10777
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10777
BRITE hierarchy
Other DBs
CAS: 945721-28-8
PubChem: 313046635
LinkDB All DBs

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