| Entry |
|
|---|
| Name |
Tenofovir disoproxil phosphate |
|---|
| Formula |
C19H30N5O10P. H3PO4
|
|---|
| Exact mass |
617.1499
|
|---|
| Mol weight |
617.44
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
|
|---|
| Remark |
| Product (DG01223): | D01982<JP/US> D10605<JP/US> |
| Product (mixture): | D02297<JP/US> D11395<US> D11396<US> |
|
|---|
| Efficacy |
Antiviral, Reverse transcriptase inhibitor |
|---|
| Comment |
Active form of prodrug: Tenofovir [CPD: C17407]
|
|---|
| Target |
HBV reverse transcriptase [KO: K21037] HIV-1 reverse transcriptase [KO: K24802] |
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF07 Tenofovir disoproxil
D10834 Tenofovir disoproxil phosphate
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
D10834 Tenofovir disoproxil phosphate
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
D10834 Tenofovir disoproxil phosphate
Antimicrobials [BR:br08307]
Antivirals
Genome replication inhibitor
HBV reverse transcriptase inhibitor
D10834 Tenofovir disoproxil phosphate
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10834
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 40
1 C8y C 20.6991 -15.3146
2 C8y C 20.6991 -13.8460
3 N4y N 19.3705 -15.7341
4 N5x N 21.9579 -15.9439
5 N5x N 19.3705 -13.4265
6 C8y C 21.9579 -13.2167
7 C8x C 18.5313 -14.6153
8 C8x C 23.1467 -15.3146
9 N5x N 23.1467 -13.8460
10 N1a N 21.9579 -11.8880
11 C1b C 19.3705 -17.1327
12 C1c C 18.1817 -17.8320
13 O2a O 16.9929 -17.1327
14 C1b C 15.7341 -17.8320
15 P1b P 14.5453 -17.1327
16 O2b O 13.3565 -16.4334
17 O2b O 13.8460 -18.3215
18 O1c O 15.2446 -15.9439
19 C1b C 13.3565 -15.0348
20 C1b C 13.8460 -19.7201
21 O7a O 12.0978 -14.3355
22 C7a C 10.9090 -15.0348
23 O7a O 9.7202 -14.3355
24 C1c C 8.4615 -15.0348
25 C1a C 7.2727 -14.3355
26 O7a O 12.5873 -20.4893
27 C7a C 11.3985 -19.7900
28 O7a O 10.2097 -20.4893
29 C1c C 8.9510 -19.7900
30 C1a C 7.7622 -20.4893
31 O6a O 10.9090 -16.4334
32 C1a C 8.4615 -16.4334
33 O6a O 11.3985 -18.3915
34 C1a C 8.9510 -18.3915
35 C1a C 18.1817 -19.2306
36 P1b P 25.7600 -19.1100
37 O1c O 25.7600 -17.7100
38 O1c O 27.1600 -19.1100
39 O1c O 24.3600 -19.1100
40 O1c O 25.7600 -20.5100
BOND 40
1 2 5 1
2 2 6 1
3 3 7 1
4 4 8 2
5 6 9 2
6 5 7 2
7 8 9 1
8 1 2 2
9 1 3 1
10 1 4 1
11 6 10 1
12 3 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 15 17 1
19 15 18 2
20 16 19 1
21 17 20 1
22 19 21 1
23 21 22 1
24 22 23 1
25 23 24 1
26 24 25 1
27 20 26 1
28 26 27 1
29 27 28 1
30 28 29 1
31 29 30 1
32 22 31 2
33 24 32 1
34 27 33 2
35 29 34 1
36 12 35 1 #Up
37 36 37 2
38 36 38 1
39 36 39 1
40 36 40 1
|
|---|
