KEGG   DRUG: Daprodustat
Entry
D10874                      Drug                                   
Name
Daprodustat (JAN/USAN/INN);
Duvroq (TN);
Jesduvroq (TN)
Product
JESDUVROQ (GlaxoSmithKline LLC)
Formula
C19H27N3O6
Exact mass
393.1900
Mol weight
393.43
Structure
Remark
Therapeutic category: 3999
ATC code: B03XA07
Product: D10874<JP/US>
Efficacy
Anti-anemic, Prolyl hydroxylase inhibitor
  Disease
Anemia due to chronic kidney disease [DS:H01642]
Comment
Treatment of anemia, diabetic wounds, and reduction of ischemic complications
Target
EGLN (HPH) [HSA:54583 112398 112399] [KO:K09592]
  Pathway
hsa04066  HIF-1 signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B03 ANTIANEMIC PREPARATIONS
   B03X OTHER ANTIANEMIC PREPARATIONS
    B03XA Other antianemic preparations
     B03XA07 Daprodustat
      D10874  Daprodustat (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Erythropoiesis Promoters
   Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors
    Daprodustat
     D10874  Daprodustat (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D10874  Daprodustat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   HIF hydroxylase
    EGLN (HPH)
     D10874  Daprodustat (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10874
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10874
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10874
Other DBs
CAS: 960539-70-2
PubChem: 319902674
ChEBI: 229223
LinkDB
KCF data

ATOM        28
            1   N1y N    25.6200  -18.9700
            2   C5x C    25.6200  -20.3700
            3   N1y N    26.8324  -21.0700
            4   C5x C    28.0449  -20.3700
            5   C1y C    28.0449  -18.9700
            6   C5x C    26.8324  -18.2700
            7   O5x O    24.4076  -21.0700
            8   O5x O    26.8324  -16.8702
            9   O5x O    29.2760  -21.0810
            10  C1y C    24.4076  -18.2700
            11  C1y C    26.8324  -22.4698
            12  C5a C    29.2760  -18.2590
            13  N1b N    30.4812  -18.9547
            14  O5a O    29.2757  -16.8701
            15  C1b C    31.6635  -18.2719
            16  C6a C    32.8575  -18.9612
            17  C1x C    24.4076  -16.8702
            18  C1x C    23.1951  -16.1702
            19  C1x C    21.9827  -16.8702
            20  C1x C    21.9827  -18.2700
            21  C1x C    23.1951  -18.9700
            22  C1x C    25.6032  -23.1797
            23  C1x C    25.6034  -24.5797
            24  C1x C    26.8159  -25.2796
            25  C1x C    28.0451  -24.5697
            26  C1x C    28.0449  -23.1697
            27  O6a O    34.0454  -18.2752
            28  O6a O    32.8578  -20.3697
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     2   7 2
            8     6   8 2
            9     4   9 2
            10    1  10 1
            11    3  11 1
            12    5  12 1
            13   12  13 1
            14   12  14 2
            15   13  15 1
            16   15  16 1
            17   10  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   10  21 1
            23   11  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   11  26 1
            29   16  27 1
            30   16  28 2

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