KEGG   DRUG: ErenumabHelp
Entry
D10928                      Drug                                   

Name
Erenumab (USAN/INN);
Erenumab (genetical recombination) (JAN);
Erenumab-aooe;
Aimovig (TN)
Product
Sequence
(Heavy chain)
QVQLVESGGG VVQPGRSLRL SCAASGFTFS SFGMHWVRQA PGKGLEWVAV ISFDGSIKYS
VDSVKGRFTI SRDNSKNTLF LQMNSLRAED TAVYYCARDR LNYYDSSGYY HYKYYGMAVW
GQGTTVTVSS ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV
HTFPAVLQSS GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER KCCVECPPCP
APPVAGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG VEVHNAKTKP
REEQFNSTFR VVSVLTVVHQ DWLNGKEYKC KVSNKGLPAP IEKTISKTKG QPREPQVYTL
PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT
VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
QSVLTQPPSV SAAPGQKVTI SCSGSSSNIG NNYVSWYQQL PGTAPKLLIY DNNKRPSGIP
DRFSGSKSGT STTLGITGLQ TGDEADYYCG TWDSRLSAVV FGGGTKLTVL GQPKANPTVT
LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADGSPVK AGVETTKPSK QSNNKYAASS
YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS
(dimer; disulfide bridge:H22-H96, H144-L215, H157-H213, H232-H'232, H233-H'233, H236-H'236, H239-H'239, H270-H330, H376-H434, H'22-H'96, H'144-L'215, H'157-H'213, H'270-H'330, H'376-H'434, L22-L89, L138-L197, L'22-L'89, L'138-L'197)
  Type
Peptide
Remark
ATC code: N02CX07
Product: D10928<US>
Efficacy
Antimigraine, Anti-calcitonin receptor-like receptor antibody
Comment
Monoclonal antibody
Prevention of migraine
Target
CALCRL [HSA:10203] [KO:K04577]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX07 Erenumab
      D10928  Erenumab (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Calcitonin
    CALCRL
     D10928  Erenumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D10928
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10928
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10928
BRITE hierarchy
Other DBs
CAS: 1582205-90-0
PubChem: 342581785
LinkDB All DBs

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