KEGG   DRUG: GalcanezumabHelp
Entry
D10936                      Drug                                   

Name
Galcanezumab (USAN/INN);
Galcanezumab-gnlm;
Emgality (TN)
Product
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYTFG NYWMQWVRQA PGQGLEWMGA IYEGTGKTVY
IQKFADRVTI TADKSTSTAY MELSSLRSED TAVYYCARLS DYVSGFGYWG QGTTVTVSSA
STKGPSVFPL APCSRSTSES TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTKTY TCNVDHKPSN TKVDKRVESK YGPPCPPCPA PEAAGGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSQEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKGLPSS IEKTISKAKG QPREPQVYTL PPSQEEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSRLT VDKSRWQEGN
VFSCSVMHEA LHNHYTQKSL SLSLG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASKDIS KYLNWYQQKP GKAPKLLIYY TSGYHSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ GDALPPTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H133-L214, H146-H202, H225-H'225, H228-H'228, H260-H320, H366-H424, H'22-H'96, H'133-L'214, H'146-H'202, H'260-H'320, H'366-H'424, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Remark
ATC code: N02CX08
Product: D10936<US>
Efficacy
Analgesic, Antimigraine, Anti-calcitonin gene related peptide (GCRP) antibody
Comment
Monoclonal antibody
Preventive treatment of migraine
Target
CALCA (CGRP) [HSA:796] [KO:K12332]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX08 Galcanezumab
      D10936  Galcanezumab (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Circulatory system
    CALCA (CGRP)
     D10936  Galcanezumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10936
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10936
BRITE hierarchy
Other DBs
CAS: 1578199-75-3
PubChem: 346930785
LinkDB All DBs

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