KEGG   DRUG: Plozalizumab
Entry
D10972                      Drug                                   
Name
Plozalizumab (USAN/INN)
Sequence
(Heavy chain)
EVQLVESGGG LVKPGGSLRL SCAASGFTFS AYAMNWVRQA PGKGLEWVGR IRTKNNNYAT
YYADSVKDRF TISRDDSKNT LYLQMNSLKT EDTAVYYCTT FYGNGVWGQG TLVTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKKVEPKSC DKTHTCPPCP APELAGAPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Light chain)
DVVMTQSPLS LPVTLGQPAS ISCKSSQSLL DSDGKTFLNW FQQRPGQSPR RLIYLVSKLD
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCWQGTHFP YTFGQGTRLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H98, H144-H200, H220-L219, H226-H'226, H229-H'229, H261-H321, H367-H425, H'22-H'98, H'144-H'200, H'220-L'219, H'261-H'321, H'367-H'425, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Efficacy
Anti-inflammatory, Antineoplastic, C-C chemokine receptor (CCR) antagonist
  Type
Monoclonal antibody
Comment
Treatment of diabetic nephropathy and arteriovenous graft patency
Target
CCR2 (CD192) [HSA:729230] [KO:K04177]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Chemokine receptors
    CCR2 (CD192)
     D10972  Plozalizumab (USAN/INN)
Other DBs
CAS: 1610761-46-0
PubChem: 350078330
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system