KEGG   DRUG: Andexanet alfa
Entry
D11029                      Drug                                   
Name
Andexanet alfa (USAN/INN);
Andexanet alfa (genetical recombination) (JAN);
Andexxa (TN);
Ondexxya (TN)
Product
ANDEXXA (Alexion Pharmaceuticals), ANDEXXA (AstraZeneca Pharmaceuticals LP)
Sequence
(heavy chain)
IVGGQECKDG ECPWQALLIN EENEGFCGGT ILSEFYILTA AHCLYQAKRF KVRVGDRNTE
QEEGGEAVHE VEVVIKHNRF TKETYDFDIA VLRLKTPITF RMNVAPACLP ERDWAESTLM
TQKTGIVSGF GRTHEKGRQS TRLKMLEVPY VDRNSCKLSS SFIITQNMFC AGYDTKQEDA
CQGDAGGPHV TRFKDTYFVT GIVSWGEGCA RKGKYGIYTK VTAFLKWIDR SMKTRGLPKA
KSHAPEVITS SPLK
(light chan)
ANSFLFWNKY KDGDQCETSP CQNQGKCKDG LGEYTCTCLE GFEGKNCELF TRKLCSLDNG
DCDQFCHEEQ NSVVCSCARG YTLADNGKAC IPTGPYPCGK QTLER
(Disulfide bridge: H7-H12, H27-H43, H108-L98, H156-H170, H181-H209, L16-L27, L21-L36, L38-L47, L55-L66, L62-L75, L77-L90)
  Type
Peptide
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01662  Factor Xa inhibitor
Remark
Therapeutic category: 3399
ATC code: V03AB38
Product: D11029<JP/US>
Efficacy
Anticoagulant reversal (factor Xa inhibitors)
Comment
Ligand decoy
Reversal of anticoagulation caused by factor Xa inhibitors
Target
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB38 Andexanet alfa
      D11029  Andexanet alfa (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D11029  Andexanet alfa (USAN/INN); Andexanet alfa (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01662  Factor Xa inhibitor
    D11029  Andexanet alfa
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    F10
     D11029  Andexanet alfa (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11029
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11029
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11029
Other DBs
CAS: 1262449-58-0
PubChem: 350078348
LinkDB

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