KEGG   DRUG: FremanezumabHelp
Entry
D11055                      Drug                                   

Name
Fremanezumab (USAN/INN);
Fremanezumab (genetical recombination) (JAN);
Fremanezumab-vfrm;
Ajovy (TN)
Formula
C6470H9952N1716O2016S46
Exact mass
145415.6128
Mol weight
145505.5255
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS NYWISWVRQA PGKGLEWVAE IRSESDASAT
HYAEAVKGRF TISRDNAKNS LYLQMNSLRA EDTAVYYCLA YFDYGLAIQN YWGQGTLVTV
SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSNFGT QTYTCNVDHK PSNTKVDKTV ERKCCVECPP CPAPPVAGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVQFNWYV DGVEVHNAKT KPREEQFNST
FRVVSVLTVV HQDWLNGKEY KCKVSNKGLP SSIEKTISKT KGQPREPQVY TLPPSREEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPMLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPGK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCKASKRVT TYVSWYQQKP GQAPRLLIYG ASNRYLGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCSQ SYNYPYTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H98, H136-L214, H149-H205, H224-H'224, H225-H'225, H228-H'228, H231-H'231, H262-H322, H368-H426, H'22-H'98, H'136-L'214, H'149-H'205, H'262-H'322, H'368-H'426, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Remark
ATC code: N02CD03
Product: D11055<US>
Efficacy
Antimigraine, Anti-calcitonin gene related peptide (GCRP) antibody
Comment
Monoclonal antibody
Target
CALCA (CGRP) [HSA:796] [KO:K12332]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CD Calcitonin gene-related peptide (CGRP) antagonists
     N02CD03 Fremanezumab
      D11055  Fremanezumab (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antimigraine Agents
  Prophylactic
   Fremanezumab
    D11055  Fremanezumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Circulatory system
    CALCA (CGRP)
     D11055  Fremanezumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11055
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11055
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11055
BRITE hierarchy
Other DBs
CAS: 1655501-53-3
PubChem: 363669768
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