KEGG   DRUG: Vadadustat
Entry
D11078                      Drug                                   

Name
Vadadustat (JAN/USAN/INN);
Vafseo (TN)
Formula
C14H11ClN2O4
Exact mass
306.0407
Mol weight
306.7011
Structure
Remark
Therapeutic category: 3999
Product: D11078<JP>
Efficacy
Anti-anemic, Prolyl hydroxylase inhibitor
Comment
Treatment of anemia associated with chronic kidney disease (CKD)
Target
EGLN (HPH) [HSA:54583 112398 112399] [KO:K09592]
  Pathway
hsa04066  HIF-1 signaling pathway
Interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D11078  Vadadustat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   HIF hydroxylase
    EGLN (HPH)
     D11078  Vadadustat (JAN/USAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11078
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11078
Other DBs
CAS: 1000025-07-9
PubChem: 375581025
ChEMBL: CHEMBL3646221
PDB-CCD: A1Z[PDBj]
LinkDB
KCF data

ATOM        21
            1   C8x C     9.5900  -13.5100
            2   C8y C     9.5900  -14.9100
            3   C8x C    10.8024  -15.6100
            4   C8y C    12.0149  -14.9100
            5   C8x C    12.0149  -13.5100
            6   C8x C    10.8024  -12.8100
            7   X   Cl    8.3776  -15.6100
            8   C8y C    13.2460  -15.6210
            9   C8x C    13.2457  -17.0099
            10  C8y C    14.4580  -17.7102
            11  C8y C    15.6706  -17.0105
            12  N5x N    15.6709  -15.6216
            13  C8x C    14.4586  -14.9213
            14  O1a O    14.4577  -19.1096
            15  C5a C    16.8897  -17.7147
            16  N1b N    18.0894  -17.0223
            17  O5a O    16.8893  -19.1099
            18  C1b C    19.2743  -17.7067
            19  C6a C    20.4671  -17.0182
            20  O6a O    21.6555  -17.7046
            21  O6a O    20.4675  -15.6103
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     4   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   10  14 1
            16   11  15 1
            17   15  16 1
            18   15  17 2
            19   16  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 2

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