KEGG   DRUG: Rovalpituzumab
Entry
D11117                      Drug                                   
Name
Rovalpituzumab (USAN)
Formula
C6416H9894N1698O2028S46
Exact mass
144649.0427
Mol weight
144738.44
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT NYGMNWVRQA PGQGLEWMGW INTYTGEPTY
ADDFKGRVTM TTDTSTSTAY MELRSLRSDD TAVYYCARIG DSSPSDYWGQ GTLVTVSSAS
TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPELLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPG
(Light chain)
EIVMTQSPAT LSVSPGERAT LSCKASQSVS NDVVWYQQKP GQAPRLLIYY ASNRYTGIPA
RFSGSGSGTE FTLTISSLQS EDFAVYYCQQ DYTSPWTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H145-H201, H221-L214, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'96, H'145-H'201, H'221-L'214, H'262-H'322, H'368-H'426, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Anti-DLL3 antibody
  Type
Monoclonal antibody
Target
DLL3 [HSA:10683] [KO:K06051]
  Pathway
hsa04330  Notch signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Environmental information processing
   Notch signaling
    DLL3
     D11117  Rovalpituzumab (USAN)
Other DBs
CAS: 1613313-01-1
PubChem: 376219041
LinkDB

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