KEGG   DRUG: Gimsilumab
Entry
D11121                      Drug                                   
Name
Gimsilumab (USAN/INN)
Formula
C6726H10428N1764O2184S38
Exact mass
152070.8542
Mol weight
152163.81
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS RHWMHWLRQV PGKGPVWVSR INGAGTSITY
ADSVRGRFTI SRDNANNTLF LQMNSLRADD TALYFCARAN SVWFRGLFDY WGQGTPVTVS
SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKKVE PKSCDKTHTC PPCPAPELLG
GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD
ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR
WQQGNVFSCS VVHEALHNHY TQKSLSLSPG K
(Light chain)
EIVLTQSPVT LSVSPGERVT LSCRASQSVS TNLAWYQQKL GQGPRLLIYG ASTRATDIPA
RFSGSGSETE FTLTISSLQS EDFAVYYCQQ YDKWPDTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H148-H204, H224-L214, H230-H'230, H233-H'233, H265-H325, H371-H429, H'22-H'96, H'148-H'204, H'224-L'214, H'265-H'325, H'371-H'429, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Anti-inflammatory
  Type
Monoclonal antibody
Comment
Treatment of rheumatoid arthritis
Target
CSF2 [HSA:1437] [KO:K05427]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04668  TNF signaling pathway
hsa05323  Rheumatoid arthritis
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   CSF and other factors
    CSF2
     D11121  Gimsilumab (USAN/INN)
Other DBs
CAS: 1648796-29-5
PubChem: 376219045
LinkDB

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