KEGG   DRUG: LumateperoneHelp
Entry
D11169                      Drug                                   

Name
Lumateperone (USAN/INN)
Formula
C24H28FN3O
Exact mass
393.2216
Mol weight
393.497
Structure
Mol fileKCF fileDB search
Remark
Chemical structure group: DG02937
Efficacy
Antipsychotic
Comment
Treatment of schizophrenia, bipolar disorder and behavioral and sleep disturbances
Target
HTR2A [HSA:3356] [KO:K04157]
DRD2 [HSA:1813] [KO:K04145]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D11169  Lumateperone (USAN/INN)
   Serotonin
    HTR2A
     D11169  Lumateperone (USAN/INN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D11169  Lumateperone (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 313368-91-1
PubChem: 376219093
ChEMBL: CHEMBL3306803
LinkDB All DBs
KCF data Show

ATOM        29
            1   C8x C    13.1254  -16.5465
            2   C8y C    13.1254  -17.9428
            3   C8x C    14.3122  -18.6410
            4   C8x C    15.5689  -17.9428
            5   C8y C    15.5689  -16.5465
            6   C8x C    14.3122  -15.8484
            7   C5a C    16.7558  -15.8484
            8   C1b C    18.0125  -16.5465
            9   C1b C    19.1993  -15.8484
            10  C1b C    20.3862  -16.5465
            11  N1y N    21.5731  -15.8484
            12  C1x C    22.8298  -16.5465
            13  C1y C    24.0166  -15.8484
            14  C1y C    24.0166  -14.4521
            15  C1x C    22.8298  -13.7539
            16  C1x C    21.5731  -14.4521
            17  X   F    11.9385  -18.6410
            18  O5a O    16.7558  -14.4521
            19  C8y C    25.3446  -16.2799
            20  C8y C    26.1654  -15.1502
            21  N1y N    25.3446  -14.0206
            22  C8y C    27.5577  -15.1439
            23  N1y N    28.1971  -13.9349
            24  C1x C    27.4464  -12.6653
            25  C1x C    26.1241  -12.6716
            26  C8x C    26.0541  -17.5588
            27  C8x C    27.4464  -17.5652
            28  C8x C    28.1971  -16.3655
            29  C1a C    29.5368  -13.8359
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   11  16 1
            18    2  17 1
            19    7  18 2
            20   13  19 1
            21   19  20 1
            22   20  21 1
            23   14  21 1
            24   20  22 2
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   21  25 1
            29   19  26 2
            30   26  27 1
            31   27  28 2
            32   28  22 1
            33   23  29 1

» Japanese version   » Back

DBGET integrated database retrieval system