KEGG   DRUG: TrifaroteneHelp
Entry
D11225                      Drug                                   

Name
Trifarotene (USAN/INN);
Aklief (TN)
Product
Formula
C29H33NO4
Exact mass
459.241
Mol weight
459.5766
Structure
Mol fileKCF fileDB search
Class
Other
 DG01604  Retinol derivative
Remark
ATC code: D10AD06
Product: D11225<US>
Efficacy
Anti-acne, Retinoic acid receptor gamma agonist
  Disease
Acne vulgaris [DS:H01445]
Comment
Retinoid
Topical treatment of acne vulgaris and lamellar ichthyosis
Target
NR1B3 (RARG) [HSA:5916] [KO:K08529]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AD Retinoids for topical use in acne
     D10AD06 Trifarotene
      D11225  Trifarotene (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Retinoic acid receptor (RAR)
    NR1B3 (RARG)
     D11225  Trifarotene (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11225
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11225
BRITE hierarchy
Other DBs
CAS: 895542-09-3
PubChem: 384585203
ChEMBL: CHEMBL3707313
LinkDB All DBs
KCF data Show

ATOM        34
            1   C8x C    18.5500  -12.4600
            2   C8y C    18.5500  -13.8600
            3   C8x C    19.7624  -14.5600
            4   C8x C    20.9749  -13.8600
            5   C8y C    20.9749  -12.4600
            6   C8x C    19.7624  -11.7600
            7   C6a C    22.2060  -11.7490
            8   O6a O    23.4112  -12.4447
            9   O6a O    22.2057  -10.3601
            10  C8y C    17.3376  -14.5600
            11  C8x C    16.1421  -13.8696
            12  C8y C    14.9296  -14.5695
            13  C8y C    14.9294  -15.9695
            14  C8x C    16.1249  -16.6599
            15  C8x C    17.3374  -15.9600
            16  C8y C    13.6984  -13.8585
            17  O2a O    13.7066  -16.6754
            18  C8x C    13.6987  -12.4602
            19  C8y C    12.4863  -11.7600
            20  C8y C    11.2738  -12.4598
            21  C8x C    11.2736  -13.8581
            22  C8x C    12.4859  -14.5583
            23  N1y N    10.0587  -11.7580
            24  C1x C     9.9131  -10.3700
            25  C1x C     8.5480  -10.0795
            26  C1x C     7.8499  -11.2881
            27  C1x C     8.7836  -12.3255
            28  C1d C    12.4863  -10.3600
            29  C1a C    13.8863  -10.3600
            30  C1a C    11.0863  -10.3600
            31  C1a C    12.4863   -8.9600
            32  C1b C    12.4977  -15.9774
            33  C1b C    11.3170  -16.6590
            34  O1a O    10.1224  -15.9691
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 2
            10    2  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   10  15 1
            17   12  16 1
            18   13  17 1
            19   16  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   16  22 1
            25   20  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   23  27 1
            31   19  28 1
            32   28  29 1
            33   28  30 1
            34   28  31 1
            35   17  32 1
            36   32  33 1
            37   33  34 1

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