KEGG   DRUG: Bermekimab
Entry
D11253                      Drug                                   
Name
Bermekimab (USAN)
Formula
C6464H10024N1736O2000S44
Exact mass
145376.3749
Mol weight
145466.0466
Sequence
(Heavy chain)
QVQLVESGGG VVQPGRSLRL SCTASGFTFS MFGVHWVRQA PGKGLEWVAA VSYDGSNKYY
AESVKGRFTI SRDNSKNILF LQMDSLRLED TAVYYCARGR PKVVIPAPLA HWGQGTLVTF
SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV EPKSCDKTHT CPPCPAPELL
GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ
YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR
EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS
RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Light chain)
DIQMTQSPSS VSASVGDRVT ITCRASQGIS SWLAWYQQKP GKAPKLLIYE ASNLETGVPS
RFSGSGSGSD FTLTISSLQP EDFATYYCQQ TSSFLLSFGG GTKVEHKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H149-H205, H225-L214, H231-H'231, H234-H'234, H266-H326, H372-H430, H'22-H'96, H'149-H'205, H'225-L'214, H'266-H'326, H'372-H'430, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Remark
ATC code: L01FX11
Efficacy
Anti-inflammatory
Comment
Monoclonal antibody
Treatment of inframmatory disease
Target
IL1A [HSA:3552] [KO:K04383]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FX Other monoclonal antibodies and antibody drug conjugates
     L01FX11 Bermekimab
      D11253  Bermekimab (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL1A
     D11253  Bermekimab (USAN)
Other DBs
CAS: 1401965-15-8
PubChem: 384585231
LinkDB

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