KEGG   DRUG: Seladelpar lysine
Entry
D11257                      Drug                                   
Name
Seladelpar lysine (USAN);
Seladelpar lysine dihydrate;
Livdelzi (TN)
Product
LIVDELZI (Gilead Sciences)
Formula
C21H23F3O5S. C6H14N2O2. 2H2O
Exact mass
626.2485
Mol weight
626.68
Structure
Remark
Chemical structure group: DG02957
Product (DG02957): D11257<US>
Efficacy
Anti-inflammatory, Peroxisome proliferator-activated receptor (PPAR) delta agonist
  Disease
Primary biliary cholangitis [DS:H01467]
Comment
Treatment of homozygous familial hypercholesterolemia (HoFH)
Target
NR1C3 (PPARG) [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway
hsa04932  Non-alcoholic fatty liver disease
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C3 (PPARG)
     D11257  Seladelpar lysine (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11257
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11257
Other DBs
CAS: 928821-40-3
PubChem: 384585235
LinkDB
KCF data

ATOM        42
            1   C8x C    11.4314  -16.5510
            2   C8y C    11.4314  -17.9536
            3   C8x C    12.6236  -18.6549
            4   C8x C    13.8158  -17.9536
            5   C8y C    13.8158  -16.5510
            6   C8x C    12.6236  -15.8497
            7   O2a O    15.0782  -15.8497
            8   C1b C    16.2704  -16.5510
            9   C1c C    17.4627  -15.8497
            10  C1b C    18.6549  -16.5510
            11  S2a S    19.8471  -15.8497
            12  C8y C    21.0394  -16.5510
            13  C8x C    21.0394  -17.9536
            14  C8y C    22.3017  -18.6549
            15  C8y C    23.4940  -17.9536
            16  C8x C    23.4940  -16.5510
            17  C8x C    22.3017  -15.8497
            18  C1a C    22.3017  -20.0575
            19  O2a O    24.7563  -18.6549
            20  C1b C    25.9486  -17.9536
            21  C6a C    27.1408  -18.6549
            22  O6a O    28.3330  -17.9536
            23  O6a O    27.1408  -20.0575
            24  C1d C    10.1690  -18.6549
            25  X   F     8.9768  -19.3562
            26  X   F     9.4677  -17.3925
            27  X   F    10.8703  -19.8471
            28  O2a O    17.4627  -14.4470
            29  C1b C    18.6549  -13.7457
            30  C1a C    18.6549  -12.3431
            31  C1c C    33.9587  -17.9995
            32  C1b C    35.2194  -17.2991
            33  C6a C    32.8380  -17.2291
            34  N1a N    34.0287  -19.4003
            35  C1b C    36.4101  -17.9995
            36  O6a O    31.5773  -17.9295
            37  O6a O    32.8380  -15.8283
            38  C1b C    37.6008  -17.3692
            39  C1b C    38.8615  -18.0696
            40  N1a N    40.0522  -17.3692
            41  O0  O    37.8000  -13.5100
            42  O0  O    37.8000  -14.8400
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19   14  18 1
            20   15  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   21  23 2
            25    2  24 1
            26   24  25 1
            27   24  26 1
            28   24  27 1
            29    9  28 1 #Up
            30   28  29 1
            31   29  30 1
            32   31  32 1
            33   31  33 1
            34   31  34 1 #Down
            35   32  35 1
            36   33  36 1
            37   33  37 2
            38   35  38 1
            39   38  39 1
            40   39  40 1

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