KEGG   DRUG: Eptinezumab
Entry
D11303                      Drug                                   

Name
Eptinezumab (USAN);
Eptinezumab-jjmr;
Vyepti (TN)
Product
Formula
C6352H9838N1694O1992S46
Exact mass
143192.7752
Mol weight
143281.2247
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAVSGIDLS GYYMNWVRQA PGKGLEWVGV IGINGATYYA
SWAKGRFTIS RDNSKTTVYL QMNSLRAEDT AVYFCARGDI WGQGTLVTVS SASTKGPSVF
PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS SGLYSLSSVV
TVPSSSLGTQ TYICNVNHKP SNTKVDARVE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK
PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY ASTYRVVSVL
TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE EMTKNQVSLT
CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS
VMHEALHNHY TQKSLSLSPG K
(Light chain)
QVLTQSPSSL SASVGDRVTI NCQASQSVYH NTYLAWYQQK PGKVPKQLIY DASTLASGVP
SRFSGSGSGT DFTLTISSLQ PEDVATYYCL GSYDCTNGDC FVFGGGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H95, H138-H194, H214-L219, H220-H'220, H223-H'223, H255-H315, H361-H419, H'22-H'95, H'138-H'194, H'214-L'219, H'255-H'315, H'361-H'419, L22-L89, L139-L199, L'22-L'89, L'139-L'199)
  Type
Peptide
Remark
Product: D11303<US>
Efficacy
Antimigraine, Anti-calcitonin gene-related peptide (GCRP) antibody
Comment
Monoclonal antibody
Prevention of migraine
Target
CALCA (CGRP) [HSA:796] [KO:K12332]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Circulatory system
    CALCA (CGRP)
     D11303  Eptinezumab (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11303
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11303
Other DBs
CAS: 1644539-04-7
PubChem: 384585281
LinkDB

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