KEGG   DRUG: Otilimab
Entry
D11343                      Drug                                   
Name
Otilimab (USAN);
Otilimab (genetical recombination) (JAN)
Formula
C6322H9768N1684O1966S44
Exact mass
142142.3848
Mol weight
142230.25
Sequence
(Heavy chain)
QVQLVESGGG LVQPGGSLRL SCAASGFTFS SYWMNWVRQA PGKGLEWVSG IENKYAGGAT
YYAASVKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR GFGTDFWGQG TLVTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKRVEPKSC DKTHTCPPCP APELLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Light chain)
DIELTQPPSV SVAPGQTARI SCSGDSIGKK YAYWYQQKPG QAPVLVIYKK RPSGIPERFS
GSNSGNTATL TISGTQAEDE ADYYCSAWGD KGMVFGGGTK LTVLGQPKAA PSVTLFPPSS
EELQANKATL VCLISDFYPG AVTVAWKADS SPVKAGVETT TPSKQSNNKY AASSYLSLTP
EQWKSHRSYS CQVTHEGSTV EKTVAPTECS
(Disulfide bridge: H22-H98, H144-H200, H220-L209, H226-H'226, H229-H'229, H261-H321, H367-H425, H'22-H'98, H'144-H'200, H'220-L'209, H'261-H'321, H'367-H'425, L22-L85, L132-L191, L'22-L'85, L'132-L'191)
  Type
Peptide
Efficacy
Antirheumatic, Anti-granulocyte-macrophage colony stimulating factor (GM-CSF) antibody
  Type
Monoclonal antibody
Comment
Treatment of osteoarthritis and rheumatoid arthritis
Target
CSF2 [HSA:1437] [KO:K05427]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04657  IL-17 signaling pathway
hsa05323  Rheumatoid arthritis
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   CSF and other factors
    CSF2
     D11343  Otilimab (USAN)
Other DBs
CAS: 1638332-55-4
PubChem: 384585321
LinkDB

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