KEGG   DRUG: Tagraxofusp
Entry
D11358                      Drug                                   
Name
Tagraxofusp (USAN/INN);
Tagraxofusp (genetical recombination) (JAN);
Tagraxofusp-erzs;
Elzonris (TN)
Product
ELZONRIS (Stemline Therapeutics)
Formula
C2553H4026N692O798S16
Exact mass
57659.1258
Mol weight
57694.51
Sequence
MGADDVVDSS KSFVMENFSS YHGTKPGYVD SIQKGIQKPK SGTQGNYDDD WKGFYSTDNK
YDAAGYSVDN ENPLSGKAGG VVKVTYPGLT KVLALKVDNA ETIKKELGLS LTEPLMEQVG
TEEFIKRFGD GASRVVLSLP FAEGSSSVEY INNWEQAKAL SVELEINFET RGKRGQDAMY
EYMAQACAGN RVRRSVGSSL SCINLDWDVI RDKTKTKIES LKEHGPIKNK MSESPNKTVS
EEKAKQYLEE FHQTALEHPE LSELKTVTGT NPVFAGANYA AWAVNVAQVI DSETADNLEK
TTAALSILPG IGSVMGIADG AVHHNTEEIV AQSIALSSLM VAQAIPLVGE LVDIGFAAYN
FVESIINLFQ VVHNSYNRPA YSPGHKTRPH MAPMTQTTSL KTSWVNCSNM IDEIITHLKQ
PPLPLLDFNN LNGEDQDILM ENNLRRPNLE AFNRAVKSLQ NASAIESILK NLLPCLPLAT
AAPTRHPIHI KDGDWNEFRR KLTFYLKTLE NAQAQQTTLS LAIF
(Disulfide bridge: 187-202, 407-475)
  Type
Peptide
Remark
Therapeutic category: 4291
ATC code: L01XX67
Product: D11358<US>
Efficacy
Antineoplastic, Immunotoxin
Comment
Fusion protein, diphteria toxin-interleukin 3
Treatment of blastic plasmacytoid dendritic cell neoplasm (CD123-directed)
Target
IL3RA (CD123) [HSA:3563] [KO:K04737]
  Pathway
hsa04210  Apoptosis
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX67 Tagraxofusp
      D11358  Tagraxofusp (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Anti-CD123 Antibodies
    Tagraxofusp
     D11358  Tagraxofusp (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D11358  Tagraxofusp (USAN/INN); Tagraxofusp (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Signaling molecules and receptors
  Cytokine receptors
   Interleukin receptors
    IL3RA (CD123)
     D11358  Tagraxofusp (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11358
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11358
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11358
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11358
Other DBs
CAS: 2055491-00-2
PubChem: 384585336
LinkDB

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