| Entry |
|
|---|
| Name |
Tenofovir disoproxil maleate |
|---|
| Formula |
C19H30N5O10P. C4H4O4
|
|---|
| Exact mass |
635.184
|
|---|
| Mol weight |
635.5149
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
|
|---|
| Remark |
| Product (DG01223): | D01982<JP/US> D10605<JP/US> |
| Product (mixture): | D11395<US> D11396<US> |
|
|---|
| Efficacy |
Antiviral, Reverse transcriptase inhibitor |
|---|
| Target |
HBV reverse transcriptase [KO: K21037] HIV-1 reverse transcriptase [KO: K24802] |
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF07 Tenofovir disoproxil
D11391 Tenofovir disoproxil maleate
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
D11391 Tenofovir disoproxil maleate
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
D11391 Tenofovir disoproxil maleate
Antimicrobials [BR:br08307]
Antivirals
Genome replication inhibitor
HBV reverse transcriptase inhibitor
D11391 Tenofovir disoproxil maleate
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D11391
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 43
1 C8y C 24.1342 -15.3190
2 C8y C 24.1342 -13.8501
3 N4y N 22.8051 -15.7387
4 N5x N 25.3933 -15.9486
5 N5x N 22.8051 -13.4304
6 C8y C 25.3933 -13.2205
7 C8x C 21.9657 -14.6195
8 C8x C 26.5824 -15.3190
9 N5x N 26.5824 -13.8501
10 N1a N 25.3933 -11.8915
11 C1b C 22.8051 -17.1377
12 C1c C 21.6160 -17.8372
13 O2a O 20.4268 -17.1377
14 C1b C 19.1677 -17.8372
15 P1b P 17.9786 -17.1377
16 O2b O 16.7894 -16.4382
17 O2b O 17.2791 -18.3269
18 O3b O 18.6781 -15.9486
19 C1b C 16.7894 -15.0392
20 C1b C 17.2791 -19.7259
21 O7a O 15.5303 -14.3397
22 C7a C 14.3412 -15.0392
23 O7a O 13.1520 -14.3397
24 C1c C 11.8929 -15.0392
25 C1a C 10.7038 -14.3397
26 O7a O 16.0200 -20.4953
27 C7a C 14.8308 -19.7958
28 O7a O 13.6417 -20.4953
29 C1c C 12.3826 -19.7958
30 C1a C 11.1934 -20.4953
31 O6a O 14.3412 -16.4382
32 C1a C 11.8929 -16.4382
33 O6a O 14.8308 -18.3968
34 C1a C 12.3826 -18.3968
35 C1a C 21.6160 -19.2362
36 C2b C 28.7700 -18.0600
37 C2b C 30.1700 -18.0600
38 C6a C 30.8700 -19.2724
39 C6a C 28.0700 -19.2724
40 O6a O 26.6702 -19.2724
41 O6a O 28.7604 -20.4679
42 O6a O 32.2698 -19.2724
43 O6a O 30.1796 -20.4679
BOND 43
1 2 5 1
2 2 6 1
3 3 7 1
4 4 8 2
5 6 9 2
6 5 7 2
7 8 9 1
8 1 2 2
9 1 3 1
10 1 4 1
11 6 10 1
12 3 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 15 17 1
19 15 18 2
20 16 19 1
21 17 20 1
22 19 21 1
23 21 22 1
24 22 23 1
25 23 24 1
26 24 25 1
27 20 26 1
28 26 27 1
29 27 28 1
30 28 29 1
31 29 30 1
32 22 31 2
33 24 32 1
34 27 33 2
35 29 34 1
36 12 35 1 #Up
37 36 37 2
38 37 38 1
39 36 39 1
40 39 40 1
41 39 41 2
42 38 42 2
43 38 43 1
|
|---|
