KEGG   DRUG: Tenofovir disoproxil maleate
Entry
D11391                      Drug                                   
Name
Tenofovir disoproxil maleate
Formula
C19H30N5O10P. C4H4O4
Exact mass
635.184
Mol weight
635.5149
Structure
Simcomp
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Remark
ATC code: J05AF07
Chemical structure group: DG01223
Product (DG01223): D01982<JP/US> D10605<JP/US>
Product (mixture): D11395<US> D11396<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
Target
HBV reverse transcriptase [KO:K21037]
HIV-1 reverse transcriptase [KO:K24802]
  Pathway
ko05161  Hepatitis B
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF07 Tenofovir disoproxil
      D11391  Tenofovir disoproxil maleate
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG01223  Tenofovir
    D11391  Tenofovir disoproxil maleate
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    DG01223  Tenofovir
     D11391  Tenofovir disoproxil maleate
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D11391  Tenofovir disoproxil maleate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11391
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG01223  Tenofovir
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    DG01223  Tenofovir
Other DBs
CAS: 1276030-80-8
PubChem: 384585369
LinkDB
KCF data

ATOM        43
            1   C8y C    24.1342  -15.3190
            2   C8y C    24.1342  -13.8501
            3   N4y N    22.8051  -15.7387
            4   N5x N    25.3933  -15.9486
            5   N5x N    22.8051  -13.4304
            6   C8y C    25.3933  -13.2205
            7   C8x C    21.9657  -14.6195
            8   C8x C    26.5824  -15.3190
            9   N5x N    26.5824  -13.8501
            10  N1a N    25.3933  -11.8915
            11  C1b C    22.8051  -17.1377
            12  C1c C    21.6160  -17.8372
            13  O2a O    20.4268  -17.1377
            14  C1b C    19.1677  -17.8372
            15  P1b P    17.9786  -17.1377
            16  O2b O    16.7894  -16.4382
            17  O2b O    17.2791  -18.3269
            18  O3b O    18.6781  -15.9486
            19  C1b C    16.7894  -15.0392
            20  C1b C    17.2791  -19.7259
            21  O7a O    15.5303  -14.3397
            22  C7a C    14.3412  -15.0392
            23  O7a O    13.1520  -14.3397
            24  C1c C    11.8929  -15.0392
            25  C1a C    10.7038  -14.3397
            26  O7a O    16.0200  -20.4953
            27  C7a C    14.8308  -19.7958
            28  O7a O    13.6417  -20.4953
            29  C1c C    12.3826  -19.7958
            30  C1a C    11.1934  -20.4953
            31  O6a O    14.3412  -16.4382
            32  C1a C    11.8929  -16.4382
            33  O6a O    14.8308  -18.3968
            34  C1a C    12.3826  -18.3968
            35  C1a C    21.6160  -19.2362
            36  C2b C    28.7700  -18.0600
            37  C2b C    30.1700  -18.0600
            38  C6a C    30.8700  -19.2724
            39  C6a C    28.0700  -19.2724
            40  O6a O    26.6702  -19.2724
            41  O6a O    28.7604  -20.4679
            42  O6a O    32.2698  -19.2724
            43  O6a O    30.1796  -20.4679
BOND        43
            1     2   5 1
            2     2   6 1
            3     3   7 1
            4     4   8 2
            5     6   9 2
            6     5   7 2
            7     8   9 1
            8     1   2 2
            9     1   3 1
            10    1   4 1
            11    6  10 1
            12    3  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   15  17 1
            19   15  18 2
            20   16  19 1
            21   17  20 1
            22   19  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   20  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   22  31 2
            33   24  32 1
            34   27  33 2
            35   29  34 1
            36   12  35 1 #Up
            37   36  37 2
            38   37  38 1
            39   36  39 1
            40   39  40 1
            41   39  41 2
            42   38  42 2
            43   38  43 1

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