| Entry |
|
|---|
| Name |
Nomacopan (USAN/INN) |
|---|
| Formula |
C720H1107N197O244S11
|
|---|
| Exact mass |
16768.7198
|
|---|
| Mol weight |
16779.41
|
|---|
| Sequence |
DSESDCTGSE PVDAFQAFSE GKEAYVLVRS TDPKARDCLK GEPAGEKQDN TLPVMMTFKN
GTDWASTDWT FTLDGAKVTA TLGNLTQNRE VVYDSQSHHC HVDKVEKEVP DYEMWMLDAG
GLEVEVECCR QKLEELASGR NQMYPHLKDC
(Disulfide bridge: 6-128, 38-150, 100-129) |
|---|
| Type |
Peptide |
|---|
| Efficacy |
Anti-inflammatory, Complement C5 inhibitor |
|---|
| Comment |
Treatment of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome and Guillain-Barre syndrome
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04610 | Complement and coagulation cascades |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Peptidases and inhibitors
Peptidase inhibitors
alpha2M family
C5
D11473 Nomacopan (USAN/INN)
|
|---|
| Other DBs |
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|---|
| LinkDB |
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