KEGG   DRUG: Tazemetostat hydrobromide
Entry
D11485                      Drug                                   

Name
Tazemetostat hydrobromide (JAN/USAN);
Tazverik (TN)
Product
Formula
C34H44N4O4. HBr
Exact mass
652.2624
Mol weight
653.6495
Structure
Simcomp
Remark
Chemical structure group: DG03020
Product (DG03020): D11485<US>
Efficacy
Antineoplastic, histone methyltransferase inhibitor
  Disease
Epithelioid sarcoma [DS:H02427]
Comment
Treatment of epithelioid sarcoma
Target
EZH2 [HSA:2146] [KO:K11430]
  Pathway
hsa00310  Lysine degradation
hsa05206  MicroRNAs in cancer
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: SLC47A1 [HSA:55244], SLC47A2 [HSA:146802]
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    EZH2
     D11485  Tazemetostat hydrobromide (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11485
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11485
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D11485
Other DBs
CAS: 1467052-75-0
PubChem: 384585461
LinkDB
KCF data

ATOM        43
            1   C1x C     8.9644  -12.3261
            2   O2x O     8.9644  -13.7268
            3   C1x C    10.1550  -14.4272
            4   C1x C    11.4157  -13.7268
            5   N1y N    11.4157  -12.3261
            6   C1x C    10.1550  -11.6258
            7   C1b C    12.6063  -11.6258
            8   C8y C    13.8669  -12.3261
            9   C8x C    13.8669  -13.7268
            10  C8x C    15.0575  -14.4272
            11  C8y C    16.2481  -13.7268
            12  C8x C    16.2481  -12.3261
            13  C8x C    15.0575  -11.6258
            14  C8y C    17.5087  -14.4272
            15  C8x C    17.5087  -15.8279
            16  C8y C    18.6993  -16.5282
            17  C8y C    19.8899  -15.8279
            18  C8y C    19.8899  -14.4272
            19  C8x C    18.6993  -13.7268
            20  C5a C    21.0805  -13.7268
            21  N1b N    22.3411  -14.4272
            22  O5a O    21.0805  -12.3261
            23  C1b C    23.5317  -13.7268
            24  C8y C    24.7223  -14.4272
            25  C8y C    24.7223  -15.8279
            26  N4x N    25.9129  -16.5282
            27  C8y C    27.1034  -15.8279
            28  C8x C    27.1034  -14.4272
            29  C8y C    25.9129  -13.7268
            30  C1a C    25.9129  -12.3261
            31  C1a C    28.3641  -16.5282
            32  O5x O    23.4616  -16.5282
            33  C1a C    21.1505  -16.5282
            34  N1c N    18.6993  -17.9289
            35  C1y C    19.8899  -18.6292
            36  C1b C    17.5087  -18.6292
            37  C1x C    19.8899  -20.0299
            38  C1x C    21.1505  -20.7303
            39  O2x O    22.3411  -20.0299
            40  C1x C    22.3411  -18.6292
            41  C1x C    21.1505  -17.9289
            42  C1a C    16.3181  -17.9289
            43  X   Br   28.2100  -20.3700
BOND        46
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   11  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   14  19 1
            22   18  20 1
            23   20  21 1
            24   20  22 2
            25   21  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   24  29 2
            33   29  30 1
            34   27  31 1
            35   25  32 2
            36   17  33 1
            37   16  34 1
            38   34  35 1
            39   34  36 1
            40   35  37 1
            41   37  38 1
            42   38  39 1
            43   39  40 1
            44   40  41 1
            45   35  41 1
            46   36  42 1

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