KEGG   DRUG: Quetmolimab
Entry
D11498                      Drug                                   
Name
Quetmolimab (USAN)
Formula
C6438H9870N1698O2006S48
Exact mass
144600.9109
Mol weight
144690.5474
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT NYYIHWVKQA PGQGLEWIGW IYPGDGSPKF
NERFKGRTTL TADKSTNTAY MLLSSLRSED TAVYFCATGP TDGDYFDYWG QGTTVTVSSA
STKGPSVFPL APCSRSTSES TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSNFGTQTY TCNVDHKPSN TKVDKTVERK CCVECPPCPA PPAAAPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTFRV
VSVLTVVHQD WLNGKEYKCK VSNKGLPAPI EKTISKTKGQ PREPQVYTLP PSREEMTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPMLDSDG SFFLYSKLTV DKSRWQQGNV
FSCSVMHEAL HNHYTQKSLS LSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASGNIH NFLAWYQQKP GKAPKLLIYN EKTLADGVPS
RFSGSGSGTD YTLTISSLQP EDFATYFCQQ FWSTPYTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H133-L214, H146-H202, H221-H'221, H222-H'222, H225-H'225, H228-H'228, H259-H319, H365-H423, H'22-H'96, H'133-L'214, H'146-H'202, H'259-H'319, H'365-H'423, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Anti-inflammatory, Anti-fractalkine antibody
Comment
Monoclonal antibody
Treatment of rheumatoid arthritis and Crohn's disease
Target
CX3CL1 [HSA:6376] [KO:K05508]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa04668  TNF signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Chemokines
    CX3CL1
     D11498  Quetmolimab (USAN)
Other DBs
CAS: 2084037-83-0
PubChem: 384585474
LinkDB

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