KEGG   DRUG: Donanemab
Entry
D11500                      Drug                                   
Name
Donanemab (USAN/INN);
Donanemab (genetical recombination) (JAN);
Donanemab-azbt;
Kisunla (TN)
Product
Formula
C6452H10038N1708O2013S42
Exact mass
144998.3882
Mol weight
145087.78
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYDFT RYYINWVRQA PGQGLEWMGW INPGSGNTKY
NEKFKGRVTI TADESTSTAY MELSSLRSED TAVYYCAREG ITVYWGQGTT VTVSSASTKG
PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV
VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV
FSCSVMHEAL HNHYTQKSLS LSPG
(Light chain)
DIVMTQTPLS LSVTPGQPAS ISCKSSQSLL YSRGKTYLNW LLQKPGQSPQ LLIYAVSKLD
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCVQGTHYP FTFGQGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H142-H198, H218-L219, H224-H'224, H227-H'227, H259-H319, H365-H423, H'22-H'96, H'142-H'198, H'218-L'219, H'259-H'319, H'365-H'423, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Class
Neuropsychiatric agent
 DG01968  Antidementia agent
Remark
Therapeutic category: 1190
ATC code: N06DX05
Product: D11500<US>
Efficacy
Dementia therapeutic agent
  Disease
Alzheimer's disease [DS:H00056]
  Type
Monoclonal antibody
Comment
Treatment of Alzheimer's disease
Target
Amyloid beta [CPD:C16514 C16515]
  Network
nt06460  Alzheimer disease
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX05 Donanemab
      D11500  Donanemab (USAN/INN) <US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D11500  Donanemab (USAN/INN); Donanemab (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01968  Antidementia agent
   D11500  Donanemab
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01968  Antidementia agent
   D11500  Donanemab
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11500
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11500
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11500
Other DBs
CAS: 1931944-80-7
PubChem: 384585476
LinkDB

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