KEGG   DRUG: Romilkimab
Entry
D11598                      Drug                                   
Name
Romilkimab (USAN/INN)
Formula
C8754H13464N2332O2788S60
Exact mass
197784.671
Mol weight
197906.4236
Sequence
(Heavy chain)
EVQLKESGPG LVAPGGSLSI TCTVSGFSLT DSSINWVRQP PGKGLEWLGM IWGDGRIDYA
DALKSRLSIS KDSSKSQVFL EMTSLRTDDT ATYYCARDGY FPYAMDFWGQ GTSVTVSSGG
GGSGGGGSQV QLQQSGPELV KPGASVKISC KASGYSFTSY WIHWIKQRPG QGLEWIGMID
PSDGETRLNQ RFQGRATLTV DESTSTAYMQ LRSPTSEDSA VYYCTRLKEY GNYDSFYFDV
WGAGTLVTVS SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG
VHTFPAVLQS SGLYSLSSVV TVPSSSLGTK TYTCNVDHKP SNTKVDKRVE SKYGPPCPPC
PAPEFEGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSQE DPEVQFNWYV DGVEVHNAKT
KPREEQFNST YRVVSVLTVL HQDWLNGKEY KCKVSNKGLP SSIEKTISKA KGQPREPQVY
TLPPSQEEMT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSR
LTVDKSRWQE GNVFSCSVMH EALHNHYTQK SLSLSLG
(Light chain)
DIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGQSYMHWY QQKAGQPPKL LIYLASNLES
GVPARFSGSG SRTDFTLTID PVQAEDAATY YCQQNAEDSR TFGGGTKLEI KGGGGSGGGG
SDIQMTQSPA SLSVSVGDTI TLTCHASQNI DVWLSWFQQK PGNIPKLLIY KASNLHTGVP
SRFSGSGSGT GFTLTISSLQ PEDIATYYCQ QAHSYPFTFG GGTKLEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H95, H150-H224, H265-H278, H334-L335, H357-H'357, H360-H'360, H392-H452, H498-H556, H'22-H'95, H'150-H'224, H'265-H'278, H'334-L'335, H'392-H'452, H'498-H'556, L23-L92, L144-L209, L255-L315, L'23-L'92, L'144-L'209, L'255-L'315)
  Type
Peptide
Efficacy
Anti-inflammatory disease, Anti-IL-13 antibody
Comment
Monoclonal antibody
Treatment of patients with systemic sclerosis
Target
IL13 [HSA:3596] [KO:K05435]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL13
     D11598  Romilkimab (USAN/INN)
Other DBs
CAS: 1399584-78-1
PubChem: 405226465
LinkDB

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