KEGG   DRUG: Volagidemab
Entry
D11614                      Drug                                   
Name
Volagidemab (USAN/INN)
Formula
C6502H10034N1758O2032S52
Exact mass
146918.1347
Mol weight
147009.28
Sequence
(Heavy chain)
QVQLVESGGG VVQPGRSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAV MWYDGSNKDY
VDSVKGRFTI SRDNSKNTLY LQMNRLRAED TAVYYCAREK DHYDILTGYN YYYGLDVWGQ
GTTVTVSSAS TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT
FPAVLQSSGL YSLSSVVTVP SSNFGTQTYT CNVDHKPSNT KVDKTVERKC CVECPPCPAP
PVAGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV QFNWYVDGVE VHNAKTKPRE
EQFNSTFRVV SVLTVVHQDW LNGKEYKCKV SNKGLPAPIE KTISKTKGQP
1REPQVYTLPP SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT
TPPMLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQGIR NDLGWYQQKP GKAPKRLIYA ASSLQSGVPS
RFSGSGSGTE FTLTISSVQP EDFVTYYCLQ HNSNPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H142-L214, H155-H211, H230-H'230, H231-H'231, H234-H'234, H237-H'237, H268-H328, H374-H432, H'22-H'96, H'142-L'214, H'155-H'211, H'268-H'328, H'374-H'432, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antidiabetic, Hypoglycemic, Anti-glucagon receptor antibody
  Type
Monoclonal antibody
Comment
Treatment of type 1 and type 2 diabetes, defects of insulin function or insulin receptor signaling, iatrogenic hyperglycemia
Target
GCGR [HSA:2642] [KO:K04583]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04922  Glucagon signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Glucagon
    GCGR
     D11614  Volagidemab (USAN/INN)
Other DBs
CAS: 1233956-13-2
PubChem: 405226481
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system