KEGG   DRUG: Pegunigalsidase alfa
Entry
D11685                      Drug                                   
Name
Pegunigalsidase alfa (USAN/INN);
Pegunigalsidase alfa-iwxj;
Elfabrio (TN)
Product
ELFABRIO (Chiesi USA)
Formula
C2060H3130N552O601S27
Exact mass
46080.3788
Mol weight
46110.04
Sequence
GLDNGLARTP TMGWLHWERF MCNLDCQEEP DSCISEKLFM EMAELMVSEG WKDAGYEYLC
IDDCWMAPQR DSEGRLQADP QRFPHGIRQL ANYVHSKGLK LGIYADVGNK TCAGFPGSFG
YYDIDAQTFA DWGVDLLKFD GCYCDSLENL ADGYKHMSLA LNRTGRSIVY SCEWPLYMWP
FQKPNYTEIR QYCNHWRNFA DIDDSWKSIK SILDWTSFNQ ERIVDVAGPG GWNDPDMLVI
GNFGLSWNQQ VTQMALWAIM AAPLFMSNDL RHISPQAKAL LQDKDVIAIN QDPLGKQGYQ
LRQGDNFEVW ERPLSGLAWA VAMINRQEIG GPRSYTIAVA SLGKGVACNP ACFITQLLPV
KRKLGFYEWT SRLRSHINPT GTVLLQLENT MQMSLKDLLS EKDEL
  Type
Peptide
Remark
ATC code: A16AB20
Product: D11685<US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (alpha-galactosidase)
  Disease
Fabry disease [DS:H00125]
  Type
Enzyme replacement therapy product
Comment
Treatment of Fabry disease
Target
GLA* [HSA_VAR:2717v1] [HSA:2717] [KO:K01189]
  Pathway
hsa00600  Sphingolipid metabolism
hsa04142  Lysosome
  Network
nt06014  Sphingolipid degradation
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB20 Pegunigalsidase alfa
      D11685  Pegunigalsidase alfa (USAN/INN) <US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Pegunigalsidase Alfa
   D11685  Pegunigalsidase alfa (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Glycosidases
    GLA* [HSA_VAR:2717v1]
     D11685  Pegunigalsidase alfa (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11685
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11685
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11685
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D11685
Other DBs
CAS: 1644392-61-9
PubChem: 405226551
LinkDB

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