KEGG   DRUG: Crovalimab
Entry
D11696                      Drug                                   
Name
Crovalimab (USAN/INN);
Crovalimab (genetical recombination) (JAN)
Formula
C6430H9974N1726O2026S46
Exact mass
145257.7649
Mol weight
145347.3332
Sequence
(Heavy chain)
QVQLVESGGG LVQPGRSLRL SCAASGFTVH SSYYMAWVRQ APGKGLEWVG AIFTGSGAEY
KAEWAKGRVT ISKDTSKNQV VLTMTNMDPV DTATYYCASD AGYDYPTHAM HYWGQGTLVT
VSSASTKPGS VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEL
RRGPKVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKGLPSSIEK TISKAKGQPR EPQVYTLPPS
REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK
SRWQQGNVFS CSVLHEALHA HYTRKELSLS P
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQGIS SSLAWYQQKP GKAPKLLIYG ASETESGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQN TKVGSSYGNT FGGGTKVEIK RTVAAPSVFI
FPPSDEQLKS GTASVVCLLN NFYPREAKVQ WKVDNALQSG NSQESVTEQD SKDSTYSLSS
TLTLSKADYE KHKVYACEVT HQGLSSPVTK SFNRGEC
(Disulfide bridge: H22-H97, H150-H206, H226-L217, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'97, H'150-H'206, H'226-L'217, H'267-H'327, H'373-H'431, L23-L88, L137-L197, L'23-L'88, L'137-L'197)
  Type
Peptide
Efficacy
Anti-complement C5 antibody
Comment
Monoclonal antibody
Treatment of paroxysmal nocturnal hemoglobinuria (PNH)
Target
C5 [HSA:727] [KO:K03994]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    C5
     D11696  Crovalimab (USAN/INN)
Other DBs
CAS: 1917321-26-6
PubChem: 405226562
LinkDB

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