KEGG   DRUG: Luspatercept
Entry
D11701                      Drug                                   
Name
Luspatercept (USAN/INN);
Luspatercept (genetical recombination) (JAN);
Luspatercept-aamt;
Reblozyl (TN)
Product
REBLOZYL (Celgene Corporation)
Formula
C3350H5070N906O1044S38
Exact mass
75910.0875
Mol weight
75958.0146
Sequence
ETRECIYYNA NWELERTNQS GLERCEGEQD KRLHCYASWR NSSGTIELVK KGCWDDDFNC
YDRQECVATE ENPQVYFCCC EGNFCNERFT HLPEAGGPEV TYEPPPTGGG THTCPPCPAP
ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR
EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP
PSREEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV
DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK
(Disulfide bridge: 5-35, 25-53, 60-79, 66-78, 80-85, 114-114', 117-117', 149-209, 255-313, 5'-35', 25'-53', 60'-79', 66'-78', 80'-85', 149'-209', 255'-313')
  Type
Peptide
Remark
Therapeutic category: 3399
ATC code: B03XA06
Product: D11701<JP/US>
Efficacy
Anti-anemic, Erythroid maturation agent
  Disease
beta Thalassemia [DS:H00228]
Comment
Treatment of anemia associated with ineffective erythropoiesis
Target
ACVR2B [HSA:93] [KO:K13596]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04350  TGF-beta signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B03 ANTIANEMIC PREPARATIONS
   B03X OTHER ANTIANEMIC PREPARATIONS
    B03XA Other antianemic preparations
     B03XA06 Luspatercept
      D11701  Luspatercept (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Blood Products and Modifiers, Other
   Blood Products and Modifiers, Micellaneous
    Luspatercept
     D11701  Luspatercept (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D11701  Luspatercept (USAN/INN); Luspatercept (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor serine/threonine kinases (RSTK)
   TGFBR2 family
    ACVR2B
     D11701  Luspatercept (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11701
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11701
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11701
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11701
Other DBs
CAS: 1373715-00-4
PubChem: 405226567
LinkDB

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