KEGG   DRUG: Lazucirnon
Entry
D11741                      Drug                                   
Name
Lazucirnon (USAN)
Formula
C27H34ClN5O3
Exact mass
511.235
Mol weight
512.0436
Structure
Remark
Chemical structure group: DG03095
Efficacy
Immunomodulator
Comment
Treatment of wet age-related macular degeneration, Parkinson's disease, Alzheimer's disease and/or eosinophilic disease
Target
CCL11 [HSA:6356] [KO:K16597]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Chemokines
    CCL11
     D11741  Lazucirnon (USAN)
Other DBs
CAS: 1251528-23-0
PubChem: 405226607
LinkDB
KCF data

ATOM        36
            1   N1y N    14.9104  -16.1004
            2   C1x C    14.9104  -17.5004
            3   C1x C    16.1704  -18.2004
            4   C1y C    17.3604  -17.5004
            5   C1x C    17.3604  -16.1004
            6   C1x C    16.1704  -15.4003
            7   N1y N    18.5505  -18.2004
            8   C5x C    18.1305  -19.5305
            9   C1x C    19.2505  -20.3705
            10  C1x C    20.3705  -19.5305
            11  C1y C    19.9505  -18.2004
            12  O5x O    16.8004  -19.9505
            13  C5a C    21.1406  -17.5004
            14  N1b N    22.3306  -18.2004
            15  C8y C    23.5487  -17.5103
            16  O5a O    21.1406  -16.1004
            17  N5x N    24.7302  -18.2054
            18  C8y C    25.9484  -17.5154
            19  C8x C    25.9599  -16.1154
            20  C8y C    24.7784  -15.4202
            21  C8x C    23.4902  -16.1103
            22  C1a C    27.1649  -18.2313
            23  C5a C    24.8068  -14.0005
            24  N1c N    26.0129  -13.3358
            25  O5a O    23.5894  -13.2648
            26  C1a C    27.2471  -14.0808
            27  C1a C    26.0405  -11.9702
            28  C1b C    13.7033  -15.3901
            29  C8y C    12.4937  -16.0754
            30  C8x C    11.2734  -15.3570
            31  C8x C    10.0551  -16.0467
            32  C8y C    10.1132  -17.4467
            33  C8y C    11.2635  -18.1650
            34  C8x C    12.4818  -17.4754
            35  X   Cl    8.8861  -18.1612
            36  C1a C    11.3024  -19.5995
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    7  11 1
            13    8  12 2
            14   13  14 1
            15   11  13 1 #Up
            16   14  15 1
            17   13  16 2
            18   15  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   15  21 1
            24   18  22 1
            25   20  23 1
            26   23  24 1
            27   23  25 2
            28   24  26 1
            29   24  27 1
            30    1  28 1
            31   28  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   29  34 1
            38   32  35 1
            39   33  36 1

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