KEGG   DRUG: Lazucirnon hydrochloride
Entry
D11742                      Drug                                   
Name
Lazucirnon hydrochloride (USAN)
Formula
C27H34ClN5O3. 2HCl
Exact mass
583.1884
Mol weight
584.9654
Structure
Remark
Chemical structure group: DG03095
Efficacy
Immunomodulator
Comment
Treatment of wet age-related macular degeneration, Parkinson's disease, Alzheimer's disease and/or eosinophilic disease
Target
CCL11 [HSA:6356] [KO:K16597]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Chemokines
    CCL11
     D11742  Lazucirnon hydrochloride (USAN)
Other DBs
CAS: 1372127-19-9
PubChem: 405226608
LinkDB
KCF data

ATOM        38
            1   C1b C    13.7283  -16.0393
            2   N1y N    14.9190  -16.7397
            3   C1x C    14.9190  -18.1406
            4   C1x C    16.1798  -18.8410
            5   C1y C    17.3705  -18.1406
            6   C1x C    17.3705  -16.7397
            7   C1x C    16.1798  -16.0393
            8   N1y N    18.5612  -18.8410
            9   C5x C    18.1409  -20.1718
            10  C1x C    19.2616  -21.0123
            11  C1x C    20.3823  -20.1718
            12  C1y C    19.9620  -18.8410
            13  O5x O    16.8101  -20.5920
            14  C5a C    21.1528  -18.1406
            15  N1b N    22.3435  -18.8410
            16  C8y C    23.5342  -18.1406
            17  O5a O    21.1528  -16.7397
            18  N5x N    24.7249  -18.8410
            19  C8y C    25.9857  -18.1406
            20  C8x C    25.9857  -16.7397
            21  C8y C    24.7950  -16.0393
            22  C8x C    23.5342  -16.7397
            23  C1a C    27.1764  -18.8410
            24  C5a C    24.7950  -14.6385
            25  N1c N    26.0557  -14.0081
            26  O5a O    23.6042  -13.8680
            27  C1a C    27.2464  -14.7085
            28  C1a C    26.0557  -12.6072
            29  C8y C    12.5080  -16.7307
            30  C8x C    11.3174  -16.0303
            31  C8x C    10.0993  -16.7203
            32  C8y C    10.0878  -18.1202
            33  C8y C    11.2783  -18.8207
            34  C8x C    12.4965  -18.1307
            35  X   Cl    8.8595  -18.8159
            36  C1a C    11.2668  -20.2300
            37  X   Cl   18.2000  -12.5300
            38  X   Cl   18.2000  -12.5300
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   7 1
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    8  12 1
            14    9  13 2
            15   14  15 1
            16   12  14 1 #Up
            17   15  16 1
            18   14  17 2
            19   16  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   16  22 1
            25   19  23 1
            26   21  24 1
            27   24  25 1
            28   24  26 2
            29   25  27 1
            30   25  28 1
            31    1  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   29  34 1
            38   32  35 1
            39   33  36 1
BRACKET     1    16.5200  -13.4400   16.5200  -11.4100
            1    19.2500  -11.4800   19.2500  -13.5100
            1  2
 ORIGINAL  1   37
 REPEAT    1   38

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