KEGG   DRUG: Tarextumab
Entry
D11775                      Drug                                   
Name
Tarextumab (USAN/INN)
Formula
C6338H9804N1700O1990S48
Exact mass
143106.4819
Mol weight
143195.07
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SSGMSWVRQA PGKGLEWVSV IASSGSNTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARSI FYTTWGQGTL VTVSSASTKG
PSVFPLAPCS RSTSESTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
SSVVTVPSSN FGTQTYTCNV DHKPSNTKVD KTVERKCCVE CPPCPAPPVA GPSVFLFPPK
PKDTLMISRT PEVTCVVVDV SHEDPEVQFN WYVDGVEVHN AKTKPREEQF NSTFRVVSVL
TVVHQDWLNG KEYKCKVSNK GLPAPIEKTI SKTKGQPREP QVYTLPPSRE EMTKNQVSLT
CLVKGFYPSD IAVEWESNGQ PENNYKTTPP MLDSDGSFFL YSKLTVDKSR WQQGNVFSCS
VMHEALHNHY TQKSLSLSPG K
(Light chain)
DIVLTQSPAT LSLSPGERAT LSCRASQSVR SNYLAWYQQK PGQAPRLLIY GASSRATGVP
ARFSGSGSGT DFTLTISSLE PEDFAVYYCQ QYSNFPITFG QGTKVEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H129-L215, H142-H198, H217-H'217, H218@H'218, H221-H'221, H224-H'224, H255-H315, H361-H419, H'22-H'96, H'129-L'215, H'142-H'198, H'255-H'315, H'361-H'419, L23-L89, L135-L195, L'23-L'89, L'135-L'195)
  Type
Peptide
Efficacy
Antineoplastic, Anti-Notch receptor antibody
  Type
Bispecific antibody
Comment
Treatment of cancer
Target
NOTCH2 [HSA:4853] [KO:K20994]
NOTCH3 [HSA:4854] [KO:K20995]
  Pathway
hsa04330  Notch signaling pathway
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Environmental information processing
   Notch signaling
    NOTCH2
     D11775  Tarextumab (USAN/INN)
    NOTCH3
     D11775  Tarextumab (USAN/INN)
Other DBs
CAS: 1359940-55-8
PubChem: 405226641
LinkDB

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