KEGG   DRUG: Rozibafusp alfa
Entry
D11907                      Drug                                   
Name
Rozibafusp alfa (USAN/INN)
Formula
C7020H10793N1868O2182S58
Exact mass
158030.4816
Mol weight
158128.7868
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SYWMSWVRQA PGKGLEWVAY IKQDGNEKYY
VDSVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCAREG ILWFGDLPTF WGQGTLVTVS
SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSNFGTQ TYTCNVDHKP SNTKVDKTVE RKCCVECPPC PAPPVAGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVQFNWYVD GVEVHNAKTK PREEQFNSTF
RVVSVLTVVH QDWLNGKEYK CKVSNKGLPA PIEKTISKTK GQPREPQVYT LPPSREEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPMLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGKGGG GGLPGCKWDL LIKQWVCDPL GSGSATGGSG
SVASSGSGSA THLLPGCKWD LLIKQWVCDP L
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQGIS NWLAWYQQKP EKAPKSLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YDSYPRTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H148-H204, H135-L214, H223-H'223, H224-H'224, H227-H'227, H230-H'230, H261-H321, H367-H425, H456-H467, H497-H508, H'22-H'96, H'148-H'204, H'135-L'214, H'261-H'321, H'367-H'425, H'456-H'467, H'497-H'508, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Anti-inflammatory
Comment
Fusion protein
Treatment of inflammatory disease
Target
ICOSLG (CD275) [HSA:23308] [KO:K06710]
TNFSF13B (BAFF, CD257) [HSA:10673] [KO:K05476]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04514  Cell adhesion molecules
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF13B (BAFF, CD257)
     D11907  Rozibafusp alfa (USAN/INN)
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    ICOSLG (CD275)
     D11907  Rozibafusp alfa (USAN/INN)
Other DBs
CAS: 2143449-47-0
LinkDB

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