KEGG   DRUG: Itepekimab
Entry
D11999                      Drug                                   
Name
Itepekimab (USAN/INN)
Formula
C6396H9882N1714O2024S46
Exact mass
144557.0183
Mol weight
144646.25
Sequence
(Heavy chain)
EVQLVESGGN LEQPGGSLRL SCTASGFTFS RSAMNWVRRA PGKGLEWVSG ISGSGGRTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLSAED TAAYYCAKDS YTTSWYGGMD VWGHGTTVTV
SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV ESKYGPPCPP CPAPEFLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ
EGNVFSCSVM HEALHNHYTQ KSLSLSLGK
(Light chain)
DIQMTQSPSS VSASVGDRVT ITCRASQGIF SWLAWYQQKP GKAPKLLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFAIYYCQQ ANSVPITFGQ GTRLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H136-L214, H149-H205, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'96, H'136-L'214, H'149-H'205, H'263-H'323, H'369-H'427, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Efficacy
Antiasthmatic, Anti-interleukin 33 antibody
  Type
Monoclonal antibody
Comment
Treatment of asthma and COPD
Target
IL33 [HSA:90865] [KO:K12967]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04217  Necroptosis
Brite
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D11999  Itepekimab
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL33
     D11999  Itepekimab (USAN/INN)
Other DBs
CAS: 2226742-52-3
PubChem: 497620412
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system