KEGG   DRUG: Zimberelimab
Entry
D12063                      Drug                                   
Name
Zimberelimab (USAN)
Formula
C6436H9878N1674O2042S40
Exact mass
144568.94
Mol weight
144657.8871
Sequence
(Heavy chain)
QLQLQESGPG LVKPSETLTL TCTVSADSIS STTYYWVWIR QPPGKGLEWI GSISYSGSTY
YNPSLKSRVT VSVDTSKNQF SLKLNSVAAT DTALYYCARH LGYNGRYLPF DYWGQGTLVT
VSSASTKGPS VFPLAPCSRS TSESTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TKTYTCNVDH KPSNTKVDKR VESKYGPPCP PCPAPEFLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS QEDPEVQFNW YVDGVEVHNA KTKPREEQFN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKG LPSSIEKTIS KAKGQPREPQ VYTLPPSQEE
MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SRLTVDKSRW
QEGNVFSCSV MHEALHNHYT QKSLSLSLGK
(Light chain)
QSALTQPASV SGSPGQSITI SCTGTSSDVG FYNYVSWYQQ HPGKAPELMI YDVSNRPSGV
SDRFSGSKSG NTASLTISGL QAEDEADYYC SSYTSISTWV FGGGTKLTVL GQPKAAPSVT
LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK AGVETTTPSK QSNNKYAASS
YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS
(Disulfide bride: H22-H97, H137-L215, H150-H206, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'97, H'137-L'215, H'150-H'206, H'264-H'324, H'370-H'428, L22-L90, L138-L197, L'22-L'90, L'138-L'197)
  Type
Peptide
Class
Antineoplastic
 DG02938  Immune checkpoint inhibitor
Efficacy
Antineoplastic
Comment
Monoclonal antibody
Target
PDCD1 (PD1, CD279) [HSA:5133] [KO:K06744]
  Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG02938  Immune checkpoint inhibitor
   D12063  Zimberelimab
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   Immune checkpoints
    PDCD1 (PD1, CD279)
     D12063  Zimberelimab (USAN)
Other DBs
CAS: 2259860-24-5
LinkDB

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