KEGG   DRUG: Tesnatilimab
Entry
D12179                      Drug                                   
Name
Tesnatilimab (USAN/INN)
Formula
C6386H9862N1688O2015S40
Exact mass
143716.9952
Mol weight
143805.3351
Sequence
(Heavy chain)
QVHLQESGPG LVKPSETLSL TCTVSDDSIS SYYWSWIRQP PGKGLEWIGH ISYSGSANYN
PSLKSRVTIS VDTSKNQFSL KLSSVTAADT AVYYCANWDD AFNIWGQGTM VTVSSASTKG
PSVFPLAPCS RSTSESTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
SSVVTVPSSS LGTKTYTCNV DHKPSNTKVD KRVESKYGPP CPPCPAPEFL GGPSVFLFPP
KPKDTLMISR TPEVTCVVVD VSQEDPEVQF NWYVDGVEVH NAKTKPREEQ FNSTYRVVSV
LTVLHQDWLN GKEYKCKVSN KGLPSSIEKT ISKAKGQPRE PQVYTLPPSQ EEMTKNQVSL
TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSRLTVDKS RWQEGNVFSC
SVMHEALHNH YTQKSLSLSL GK
(Light chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GASSRATGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPWTFG QGTKVEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H95, H129-L215, H142-H198, H221-H'221, H224-H'224, H256-H316, H362-H420, H'22-H'95, H'129-L'215, H'142-H'198, H'256-H'316, H'362- H'420, L23-L89, L135-L195, L'23-L'89, L'135-L'195)
  Type
Peptide
Efficacy
Anti-inflammatory disease
  Type
Monoclonal antibody
Comment
Treatment of Crohn's disease
Target
KLRK1 (CD314, NKG2D) [HSA:22914] [KO:K06728]
  Pathway
hsa04650  Natural killer cell mediated cytotoxicity
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    KLRK1 (CD314, NKG2D)
     D12179  Tesnatilimab (USAN/INN)
Other DBs
CAS: 2242758-08-1
LinkDB

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