KEGG   DRUG: Cadonilimab
Entry
D12190                      Drug                                   
Name
Cadonilimab (USAN)
Formula
C8772H13504N2384O2768S62
Exact mass
198513.1897
Mol weight
198635.4242
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFAFS SYDMSWVRQA PGKGLDWVAT ISGGGRYTYY
PDSVKGRFTI SRDNSKNNLY LQMNSLRAED TALYYCANRY GEAWFAYWGQ GTLVTVSSAS
TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPEAAGAPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPGKGG GGSGGGGSGG GGSGGGGSQV QLVESGAEVK
KPGASVKVSC KASGYSFTGY TMNWVRQAPG QCLEWIGLIN PYNNITNYAQ KFQGRVTFTV
 DTSISTAYME LSRLRSDDTG VYFCARLDYR SYWGQGTLVT VSAGGGGSGG GGSGGGGSGG
GGSQAVVTQE PSLTVSPGGT VTLTCGSSTG AVTTSNFPNW VQQKPGQAPR SLIGGTNNKA
SWTPARFSGS LLGGKAALTI SGAQPEDEAE YYCALWYSNH WVFGCGTKLT VLR
(Light chain)
DIQMTQSPSS MSASVGDRVT FTCRASQDIN TYLSWFQQKP GKSPKTLIYR ANRLVSGVPS
RFSGSGSGQD YTLTISSLQP EDMATYYCLQ YDEFPLTFGA GTKLELKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide birde: H22-H96, H145-H201, H221-L214, H227-H'227, H230-H'230, H262-H322, H368-H426, H490-H564, H512-H705, H625-H693, H'22-H'96, H'145-H'201, H'221-L'214, H'262-H'322, H'368-H'426, H'490-H'564, H'512-H'705, H'625-H'693, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Antineoplastic
 DG02938  Immune checkpoint inhibitor
Efficacy
Antineoplastic, Immune checkpoint inhibitor
Comment
Monoclonal antibody; bispecific antibody
Target
PDCD1 (PD1, CD279) [HSA:5133] [KO:K06744]
CTLA4 (CD152) [HSA:1493] [KO:K06538]
  Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG02938  Immune checkpoint inhibitor
   D12190  Cadonilimab
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   Immune checkpoints
    CTLA4 (CD152)
     D12190  Cadonilimab (USAN)
    PDCD1 (PD1, CD279)
     D12190  Cadonilimab (USAN)
Other DBs
CAS: 2394841-59-7
LinkDB

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